Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
17: shared signals

First condition

Second condition

Comparison

Crohn's DiseaseandSchizophrenia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

25: Crohn's Disease references
46: Schizophrenia references
0: shared references

Metals elevated or accumulated

4 shared

Shared

Lead Cadmium Arsenic Copper

Only in Crohn's Disease

Iron TissueCobalt MucosalMercuryIron MucosalNickel

Only in Schizophrenia

Iron

Metals depleted or redistributed

2 shared

Shared

Glutathione (GSH)Zinc

Only in Crohn's Disease

Zinc LuminalIron LuminalManganese LuminalCopper LuminalSelenium Manganese

Only in Schizophrenia

None indexed

Taxa enriched

2 shared

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Roseburia Lachnospiraceae

Only in Crohn's Disease

Akkermansia muciniphila Eubacterium Lachnospiraceae (Family)Lactobacillus

Only in Schizophrenia

Coprococcus Blautia Saccharomyces cerevisiae Bifidobacterium Desulfovibrio Veillonellaceae

Host response elevated

3 shared

Shared

Hepcidin Lipocalin-2 Ceruloplasmin

Only in Crohn's Disease

Calprotectin (S100A8/A9)LactoferrinPro Inflammatory CytokinesDUOX2

Only in Schizophrenia

CRPSCD14IL 6IL-1beta (Interleukin-1 Beta)TNF-alpha (Tumor Necrosis Factor Alpha)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperZonulinAlpha 1 Antitrypsin

Host response depleted

2 shared

Shared

Glutathione (GSH)Anti Inflammatory Cytokines

Only in Crohn's Disease

Alpha Defensins

Only in Schizophrenia

Total Antioxidant CapacityVitamin DSCFAsZinc Finger Proteins

Ecological state

1 shared

Shared

SCFA Depletion

Only in Crohn's Disease

Barrier DysfunctionLeaky GutHypoxia BiofilmBile Acid DysmetabolismTryptophan DepletionFermentative Metabolism FerroptosisButyrate CollapseNOD2 Paneth Cell Defect

Only in Schizophrenia

Gut Barrier DysfunctionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityGut Barrier DisruptionMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Crohn's Disease

Siderophores Zinc-MetalloproteaseIron Dependent HydrogenaseCobalt Dependent EnzymesCopper Resistance DeterminantsMucin Degrading EnzymesSiderophores EnterobactinSiderophores YersiniabactinSiderophores AerobactinZinc Metalloprotease BFTFimH AdhesinOuter Membrane VesiclesNickel-Urease

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsLPS BiosynthesisSiderophore SystemsBeta-GlucuronidaseIndoleamine 2 3 DioxygenaseTryptophanase