Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

16%: weighted overlap
20: shared signals

First condition

Second condition

Comparison

Crohn's DiseaseandChronic Kidney Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

25: Crohn's Disease references
34: Chronic Kidney Disease references
0: shared references

Metals elevated or accumulated

5 shared

Shared

Lead Cadmium Mercury Arsenic Nickel

Only in Crohn's Disease

Iron TissueCobalt MucosalIron MucosalCopper

Only in Chronic Kidney Disease

ChromiumIron In Tubular CellsThallium

Metals depleted or redistributed

2 shared

Shared

Glutathione (GSH)Zinc

Only in Crohn's Disease

Zinc LuminalIron LuminalManganese LuminalCopper LuminalSelenium Manganese

Only in Chronic Kidney Disease

Alpha-Klotho

Taxa enriched

3 shared

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Roseburia Lachnospiraceae Akkermansia muciniphila

Only in Crohn's Disease

Eubacterium Lachnospiraceae (Family)Lactobacillus

Only in Chronic Kidney Disease

Lachnospira Coprococcus Prevotella Bifidobacterium Eubacterium rectale Ruminococcus bromii Anaerostipes Blautia

Host response elevated

2 shared

Shared

Hepcidin Lipocalin-2

Only in Crohn's Disease

Calprotectin (S100A8/A9)LactoferrinPro Inflammatory CytokinesDUOX2Ceruloplasmin

Only in Chronic Kidney Disease

CRPIL 6IL 18TNF-alpha (Tumor Necrosis Factor Alpha)TLR2 TLR4NF KappaBNLRP3 InflammasomeSCD14Free Light Chains KappaFree Light Chains LambdaIndoxyl SulfateP Cresyl SulfateTrimethylamine N-Oxide (TMAO)MalondialdehydeUric AcidFerritin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Crohn's Disease

Anti Inflammatory CytokinesAlpha Defensins

Only in Chronic Kidney Disease

Alpha-Klotho ButyratePropionateAcetateIndole Propionic AcidTaurineBCAAsVitamin DTotal Antioxidant CapacityENOSGPX4

Ecological state

2 shared

Shared

SCFA DepletionFerroptosis

Only in Crohn's Disease

Barrier DysfunctionLeaky GutHypoxia BiofilmBile Acid DysmetabolismTryptophan DepletionFermentative MetabolismButyrate CollapseNOD2 Paneth Cell Defect

Only in Chronic Kidney Disease

Saccharolytic To Proteolytic ShiftGut Barrier DysfunctionUremic Toxin AccumulationAmmonia PH DisruptionMetal Microbiome Co ResistanceAntibiotic Resistance Gene EnrichmentVicious Cycle BidirectionalConstipation As Progression MarkerVicious Cycle Metal AccumulationStage 3b Ecological TransitionUremic Toxin ProductionMetal Antibiotic Co ResistanceGut Barrier DisruptionDialysis Irreversibility

Virulence and functional enzymes

1 shared

Shared

Siderophores

Only in Crohn's Disease

Zinc-MetalloproteaseIron Dependent HydrogenaseCobalt Dependent EnzymesCopper Resistance DeterminantsMucin Degrading EnzymesSiderophores EnterobactinSiderophores YersiniabactinSiderophores AerobactinZinc Metalloprotease BFTFimH AdhesinOuter Membrane VesiclesNickel-Urease

Only in Chronic Kidney Disease

UreaseTryptophanaseTyrosine DecarboxylaseTMA LyaseAromatic Amino Acid Degradation EnzymesBeta-GlucuronidaseHydrogen Sulfide SynthaseCadA Cadmium ATPaseArsC Arsenate ReductaseP Cresyl Sulfate SynthaseIndoxyl Sulfate Synthase