Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

13%: weighted overlap
12: shared signals

First condition

Second condition

Comparison

Premenstrual Dysphoric DisorderandSchizophrenia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

6: Premenstrual Dysphoric Disorder references
46: Schizophrenia references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Copper

Only in Premenstrual Dysphoric Disorder

None indexed

Only in Schizophrenia

Iron Lead Cadmium Arsenic

Metals depleted or redistributed

1 shared

Taxa enriched

0 shared

Shared

None indexed

Only in Premenstrual Dysphoric Disorder

AnaerotaeniaEscherichia coli

Only in Schizophrenia

Lactobacillus Prevotella Enterobacteriaceae Streptococcus VeillonellaSuccinivibrioCandida albicansTrichosporonPurpureocillium Clostridia Betaproteobacteria Prevotellaceae

Taxa depleted

2 shared

Shared

Blautia Faecalibacterium prausnitzii

Only in Premenstrual Dysphoric Disorder

Butyricicoccus Megasphaera Parabacteroides

Only in Schizophrenia

Roseburia Coprococcus Saccharomyces cerevisiae Bifidobacterium Desulfovibrio Veillonellaceae Lachnospiraceae

Host response elevated

2 shared

Shared

IL-8 (Interleukin-8 / CXCL8)TNF-alpha (Tumor Necrosis Factor Alpha)

Only in Premenstrual Dysphoric Disorder

Pro Inflammatory CytokinesCopper Zinc Ratio

Only in Schizophrenia

CRPSCD14IL 6IL-1beta (Interleukin-1 Beta)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperCeruloplasmin Hepcidin Lipocalin-2 ZonulinAlpha 1 Antitrypsin

Host response depleted

0 shared

Shared

None indexed

Only in Premenstrual Dysphoric Disorder

Magnesium Serotonin GABA (Gamma-Aminobutyric Acid)Allopregnanolone SensitivityButyrate

Only in Schizophrenia

Glutathione (GSH)Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Ecological state

2 shared

Shared

Tryptophan Kynurenine ShuntingSCFA Depletion

Only in Premenstrual Dysphoric Disorder

Estrobolome DysfunctionGABA A Receptor ModulationLuteal Phase InflammationBeta Glucuronidase DysregulationEstrogen RecirculationBeta Glucuronidase ActivityCircadian Rhythm DisruptionMelatonin Amplitude Reduction

Only in Schizophrenia

Gut Barrier DysfunctionTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityGut Barrier DisruptionMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Virulence and functional enzymes

4 shared

Shared

Beta-GlucuronidaseTryptophanaseLPS BiosynthesisIndoleamine 2 3 Dioxygenase

Only in Premenstrual Dysphoric Disorder

IDO Upregulation

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsSiderophore Systems