Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
15: shared signals

First condition

Second condition

Comparison

Postpartum DepressionandAutism Spectrum Disorder

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

56: Postpartum Depression references
32: Autism Spectrum Disorder references
0: shared references

Metals elevated or accumulated

3 shared

Shared

Copper Cadmium Lead

Only in Postpartum Depression

None indexed

Only in Autism Spectrum Disorder

Mercury Nickel Arsenic

Metals depleted or redistributed

2 shared

Taxa enriched

1 shared

Shared

Desulfovibrio

Only in Postpartum Depression

EnterobacteriaceaeAlphaproteobacteriaBilophila Escherichia coli Dialister Enterococcus

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium Coprostanoligenes

Taxa depleted

4 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Lachnospiraceae Coprococcus

Only in Postpartum Depression

Phascolarctobacterium Veillonella Eubacterium Clostridium Butyricicoccus Holdemanella

Only in Autism Spectrum Disorder

Lactobacillus

Host response elevated

3 shared

Shared

HepcidinIL 6TNF-alpha (Tumor Necrosis Factor Alpha)

Only in Postpartum Depression

CRPIDOCeruloplasmin Copper

Only in Autism Spectrum Disorder

Calprotectin (S100A8/A9)Lactoferrin Transferrin Lipocalin-2IL 1IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Host response depleted

1 shared

Shared

Zinc

Only in Postpartum Depression

Tryptophan GABA (Gamma-Aminobutyric Acid)SCFAFerritin Selenium

Only in Autism Spectrum Disorder

Glutathione (GSH)SulfateIL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Ecological state

0 shared

Shared

None indexed

Only in Postpartum Depression

Postpartum Hormonal CrashEstrogen Progesterone WithdrawalSCFA DepletionIDO Kynurenine ActivationTryptophan DiversionHPA Axis DysregulationGut Brain Axis DisruptionBile Acid DysmetabolismPrenatal Microbiome SeedingIntergenerational Dysbiosis TransmissionBarrier DysfunctionHormonal DysregulationTryptophan Kynurenine ShuntingIntergenerational Microbiome Transmission

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Postpartum Depression

LPS EndotoxinIDO Indoleamine 2 3 DioxygenaseBile Salt Hydrolase (BSH)Sulfite ReductaseSiderophores EnterobactinSiderophoresLPS Biosynthesis Enzymes

Only in Autism Spectrum Disorder

ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production