Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

9%: weighted overlap
11: shared signals

First condition

Second condition

Comparison

Colorectal CancerandNecrotizing Enterocolitis

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

36: Colorectal Cancer references
19: Necrotizing Enterocolitis references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Iron

Only in Colorectal Cancer

Zinc Cadmium Lead Copper Nickel Arsenic Chromium

Only in Necrotizing Enterocolitis

None indexed

Metals depleted or redistributed

1 shared

Shared

Zinc

Only in Colorectal Cancer

Butyrate Selenium Manganese

Only in Necrotizing Enterocolitis

None indexed

Taxa enriched

1 shared

Shared

Escherichia coli

Only in Colorectal Cancer

Fusobacterium nucleatum Fusobacterium varium Bacteroides fragilis Parvimonas micra Peptostreptococcus stomatis Clostridium symbiosum Porphyromonas gingivalis Akkermansia muciniphila Candida albicans Peptostreptococcus anaerobius Enterococcus faecalis Streptococcus gallolyticus Saccharomyces cerevisiae

Only in Necrotizing Enterocolitis

Klebsiella Clostridium perfringens Staphylococcus Klebsiella pneumoniaeClostridium Perfringens (Toxigenic)Sphingomonas Spp.Clostridium Spp. (Obligate Anaerobe Cluster)Bacteroides/Prevotella (Obligate Anaerobe Cluster)Staphylococcus epidermidis Enterococcus

Taxa depleted

2 shared

Shared

Bifidobacterium Lactobacillus

Only in Colorectal Cancer

Lachnospiraceae Faecalibacterium prausnitzii Roseburia Prevotella copri Ruminococcus albus Dialister Ruminococcus

Only in Necrotizing Enterocolitis

BacteroidesBacteroidetes (Phylum)

Host response elevated

4 shared

Shared

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)Calprotectin (S100A8/A9)

Only in Colorectal Cancer

Lipopolysaccharide Hepcidin Lipocalin-2

Only in Necrotizing Enterocolitis

Lactoferrin EndogenousPro Inflammatory CytokinesTLR4 ExpressionLPS

Host response depleted

0 shared

Shared

None indexed

Only in Colorectal Cancer

IL-10 (Interleukin-10)IgATreg CellsSelenium Dependent Glutathione PeroxidaseGlutathione (GSH)

Only in Necrotizing Enterocolitis

Zinc Defensins AcetateLactateSecretory IgA

Ecological state

1 shared

Shared

Biofilm

Only in Colorectal Cancer

HypoxiaSecondary Bile Acid AccumulationFermentative Acidic MicroenvironmentEpithelial Barrier DisruptionColonic Serotonin DepletionAnaerobic DominanceSecondary Bile Acid ExcessSCFA DepletionWarburg EffectCross Kingdom DysbiosisVirome Network Disruption

Only in Necrotizing Enterocolitis

Proteobacteria Bloom 2 Weeks Pre DiagnosisVirome Convergence 10 Days Pre OnsetTLR4 Upregulation In Premature EpitheliumBifidobacterium Absence As PreconditionHMO Mediated Colonization ResistanceFeed Forward Barrier DestructionProteobacteria BloomTLR4 Feed Forward LoopVirome ConvergenceImmature BarrierParenteral Iron OverloadBile Acid Accumulation ASBT UpregulationMuc2 Depletion Mucosal Barrier FailureObligate Anaerobe Mucosal InvasionGut Brain Axis NDI RiskAntibiotic Driven Richness Nadir Week4

Virulence and functional enzymes

1 shared

Shared

Siderophores

Only in Colorectal Cancer

FadAFap2LPS TLR4BFT ToxinColibactin PksUrease Glyoxalase I Beta-GlucuronidaseBFT Zinc MetalloproteaseColibactin GenotoxinFadA AdhesinFap2 LectinNAD(P)H Oxidase

Only in Necrotizing Enterocolitis

LPS BiosynthesisAlpha ToxinPerfringolysin OBiofilm Formation Enzymes