Staphylococcus epidermidis is a Gram-positive, facultative anaerobic coagulase-negative staphylococcus and one of the most abundant commensals of human skin and mucosal surfaces. While generally benign, it is a leading cause of nosocomial infections associated with indwelling medical devices due to its prolific biofilm-forming capacity.

Thirteen selected Staphylococcus epidermidis cocci appear in three irregular clusters of five, four, and four.
Species representative reconstruction Editorially reviewed

Type-strain-anchored Staphylococcus epidermidis reconstruction with thirteen cocci. Representative, non-diagnostic, not visually separable from other staphylococci, and not a micrograph.

WikiBiome / Microbiome MedicineCurrent-species-taxonomy-, type-strain-, medical-morphology-, and output-audit-informed reconstruction
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Staphylococcus epidermidistaxon · species
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01
Metal Dependencies and Biofilm

S. epidermidis biofilms exhibit notable metal resistance properties. Metal-based antimicrobial strategies targeting biofilm-embedded staphylococci—including methicillin-resistant strains (MRSE)—leverage the organism's metal dependencies as vulnerabilities (). Essential oils and carvacrol-based codrugs have shown antibiofilm activity against S. epidermidi

02
Reproductive Tract Associations

Beyond skin, S. epidermidis is a component of the genital and intestinal microbiota. It has been identified in the reproductive tract microbiome of women with adenomyosis and associated infertility (), suggesting a role in reproductive tract dysbiosis.

Contents1. Metal Dependencies and Biofilm2. Reproductive Tract Associations3. Cross-References

Metal Dependencies and Biofilm#

S. epidermidis biofilms exhibit notable metal resistance properties. Metal-based antimicrobial strategies targeting biofilm-embedded staphylococci—including methicillin-resistant strains (MRSE)—leverage the organism's metal dependencies as vulnerabilities ([1]Sanchez-Rosario 2026 — N-benzyl-N-methyldithiocarbamate (BMDC) Combines with Metals to Produce Antimicrobial and Anti-Biofilm Activity Against MRSA and S. epidermidisYamil Sanchez-Rosario, Natasha R Cornejo, Isaiah S Gonzalez et al. · 2026Open reference 1 ↓).

Essential oils and carvacrol-based codrugs have shown antibiofilm activity against S. epidermidis, disrupting the polysaccharide matrix that shields sessile cells ([2]Cacciatore 2015 — Carvacrol codrugs: a new approach in the antimicrobial planIvana Cacciatore, Mara Di Giulio, Erika Fornasari et al. · 2015Open reference 2 ↓).

Reproductive Tract Associations#

Beyond skin, S. epidermidis is a component of the genital and intestinal microbiota. It has been identified in the reproductive tract microbiome of women with adenomyosis and associated infertility ([3]Ponomaryova 2022 — Changes in microbiota of genital tract and intestines in patients with adenomyosis and infertilityPonomaryova IG, Lisyana TO, Trokhimovych OV et al. · 2022Open reference 3 ↓), suggesting a role in reproductive tract Dysbiosis.

Cross-References#

  • Biofilm—S. epidermidis as a model biofilm-forming organism
  • Staphylococcus—genus-level page
  • adenomyosis—reproductive tract associations
  • Antimicrobial Metals—metal-based strategies against staphylococcal biofilms
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References 3

Numbered by first appearance in the article, then reconciled with its declared source list.

  1. 1

    Yamil Sanchez-Rosario, Natasha R Cornejo, Isaiah S Gonzalez et al. (2026). Sanchez-Rosario 2026 — N-benzyl-N-methyldithiocarbamate (BMDC) Combines with Metals to Produce Antimicrobial and Anti-Biofilm Activity Against MRSA and S. epidermidis. mSphere.

  2. 2

    Ivana Cacciatore, Mara Di Giulio, Erika Fornasari et al. (2015). Cacciatore 2015 — Carvacrol codrugs: a new approach in the antimicrobial plan. PLOS ONE.

  3. 3

    Ponomaryova IG, Lisyana TO, Trokhimovych OV et al. (2022). Ponomaryova 2022 — Changes in microbiota of genital tract and intestines in patients with adenomyosis and infertility. Medical Research Journal.

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Current recordStaphylococcus epidermidisMicroorganisms
MechanismsDysbiosisReferenced in this microorganisms recordHost defensesBiofilmReferenced in this microorganisms recordMicroorganismsStaphylococcusReferenced in this microorganisms recordHost defensesAntimicrobial MetalsReferenced in this microorganisms recordMechanismsSemen MicrobiomeLinks back from its mechanisms record
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