Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

17%: weighted overlap
19: shared signals

First condition

Second condition

Comparison

Autism Spectrum DisorderandSchizophrenia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

32: Autism Spectrum Disorder references
46: Schizophrenia references
0: shared references

Metals elevated or accumulated

4 shared

Metals depleted or redistributed

2 shared

Shared

Zinc Glutathione (GSH)

Only in Autism Spectrum Disorder

Iron Selenium

Only in Schizophrenia

None indexed

Taxa enriched

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium CoprostanoligenesDesulfovibrio

Only in Schizophrenia

Lactobacillus Prevotella Enterobacteriaceae Streptococcus VeillonellaSuccinivibrioCandida albicansTrichosporonPurpureocillium Clostridia Betaproteobacteria Prevotellaceae

Taxa depleted

4 shared

Shared

Coprococcus Bifidobacterium Faecalibacterium prausnitzii Lachnospiraceae

Only in Autism Spectrum Disorder

Lactobacillus

Only in Schizophrenia

Roseburia Blautia Saccharomyces cerevisiae Desulfovibrio Veillonellaceae

Host response elevated

5 shared

Shared

Hepcidin Lipocalin-2 TNF-alpha (Tumor Necrosis Factor Alpha)IL 6Malondialdehyde

Only in Autism Spectrum Disorder

Calprotectin (S100A8/A9)Lactoferrin TransferrinIL 1IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Only in Schizophrenia

CRPSCD14IL-1beta (Interleukin-1 Beta)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4ACeruloplasmin Bound CopperCeruloplasmin ZonulinAlpha 1 Antitrypsin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Autism Spectrum Disorder

SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Only in Schizophrenia

Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Ecological state

2 shared

Shared

Gut Barrier DysfunctionGut Barrier Disruption

Only in Autism Spectrum Disorder

Propionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Only in Schizophrenia

SCFA DepletionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Autism Spectrum Disorder

ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsLPS BiosynthesisSiderophore SystemsIndoleamine 2 3 DioxygenaseTryptophanase