Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
15: shared signals

First condition

Second condition

Comparison

Autism Spectrum DisorderandPostpartum Depression

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

32: Autism Spectrum Disorder references
56: Postpartum Depression references
0: shared references

Metals elevated or accumulated

3 shared

Shared

Lead Cadmium Copper

Only in Autism Spectrum Disorder

Mercury Nickel Arsenic

Only in Postpartum Depression

None indexed

Metals depleted or redistributed

2 shared

Taxa enriched

1 shared

Shared

Desulfovibrio

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium Coprostanoligenes

Only in Postpartum Depression

EnterobacteriaceaeAlphaproteobacteriaBilophila Escherichia coli Dialister Enterococcus

Taxa depleted

4 shared

Shared

Coprococcus Bifidobacterium Faecalibacterium prausnitzii Lachnospiraceae

Only in Autism Spectrum Disorder

Lactobacillus

Only in Postpartum Depression

Phascolarctobacterium Veillonella Eubacterium Clostridium Butyricicoccus Holdemanella

Host response elevated

3 shared

Shared

Hepcidin TNF-alpha (Tumor Necrosis Factor Alpha)IL 6

Only in Autism Spectrum Disorder

Calprotectin (S100A8/A9)Lactoferrin Transferrin Lipocalin-2IL 1IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Only in Postpartum Depression

CRPIDOCeruloplasmin Copper

Host response depleted

1 shared

Shared

Zinc

Only in Autism Spectrum Disorder

Glutathione (GSH)SulfateIL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Only in Postpartum Depression

Tryptophan GABA (Gamma-Aminobutyric Acid)SCFAFerritin Selenium

Ecological state

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Only in Postpartum Depression

Postpartum Hormonal CrashEstrogen Progesterone WithdrawalSCFA DepletionIDO Kynurenine ActivationTryptophan DiversionHPA Axis DysregulationGut Brain Axis DisruptionBile Acid DysmetabolismPrenatal Microbiome SeedingIntergenerational Dysbiosis TransmissionBarrier DysfunctionHormonal DysregulationTryptophan Kynurenine ShuntingIntergenerational Microbiome Transmission

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Autism Spectrum Disorder

ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production

Only in Postpartum Depression

LPS EndotoxinIDO Indoleamine 2 3 DioxygenaseBile Salt Hydrolase (BSH)Sulfite ReductaseSiderophores EnterobactinSiderophoresLPS Biosynthesis Enzymes