Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

21%: weighted overlap
19: shared signals

First condition

Second condition

Comparison

Alzheimer's DiseaseandGraves' Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Alzheimer's Disease references
22: Graves' Disease references
0: shared references

Metals elevated or accumulated

4 shared

Shared

Lead Cadmium Iron Mercury

Only in Alzheimer's Disease

Arsenic Manganese Copper AluminumZinc In PlaquesNickel

Only in Graves' Disease

Iodine Dysregulated

Metals depleted or redistributed

2 shared

Taxa enriched

3 shared

Shared

Escherichia coli Bacteroides fragilis Prevotella

Only in Alzheimer's Disease

Helicobacter pylori Klebsiella pneumoniae Akkermansia muciniphila Candida albicans

Only in Graves' Disease

Enterobacteriaceae Streptococcus Lactobacillus Collinsella Bifidobacterium Desulfovibrio Veillonella

Taxa depleted

3 shared

Shared

Lachnospiraceae Roseburia Faecalibacterium prausnitzii

Only in Alzheimer's Disease

Saccharomyces Ruminococcus Blautia Eubacterium rectale Bacteroides

Only in Graves' Disease

Akkermansia muciniphila Bifidobacterium Phascolarctobacterium Dialister Butyricimonas Lachnospira

Host response elevated

2 shared

Shared

Hepcidin Lipocalin-2

Only in Alzheimer's Disease

Calprotectin (S100A8/A9)Proinflammatory CytokinesTransferrin Receptor AlteredFerritin AlteredTREM2

Only in Graves' Disease

Transferrin

Host response depleted

1 shared

Shared

Selenoproteins

Only in Alzheimer's Disease

Glutathione (GSH)ButyratePropionateIndole DerivativesTryptophan MetabolitesCeruloplasmin Function

Only in Graves' Disease

Glutathione PeroxidaseThioredoxin ReductaseDeiodinases

Ecological state

1 shared

Shared

LPS Translocation

Only in Alzheimer's Disease

Hypoxia DysbiosisBarrier DysfunctionNeuroinflammationAmyloid SeedingMicroglial ActivationBlood Brain Barrier DisruptionAmyloid Cross SeedingLPS EndotoxemiaSCFA DepletionTMAO ElevationFerroptosisEpigenetic Latency

Only in Graves' Disease

Intestinal PermeabilityTh17 Treg ImbalanceMolecular Mimicry Estrogen RecirculationSCFA DeficiencyBidirectional Gut Thyroid Axis

Virulence and functional enzymes

3 shared

Shared

SiderophoresLPSBeta-Glucuronidase

Only in Alzheimer's Disease

Curli FibersLipopolysaccharideBacterial AmyloidsUreaseMetalloproteasesNickel-UreaseCurli Amyloid

Only in Graves' Disease

Thyroid Peroxidase Mimicry AntigensLPS Endotoxin