Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

21%: weighted overlap
20: shared signals

First condition

Second condition

Comparison

Type 1 DiabetesandSchizophrenia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

20: Type 1 Diabetes references
46: Schizophrenia references
0: shared references

Metals elevated or accumulated

5 shared

Shared

Cadmium Lead Arsenic Iron Copper

Only in Type 1 Diabetes

None indexed

Only in Schizophrenia

None indexed

Metals depleted or redistributed

2 shared

Shared

Zinc Glutathione (GSH)

Only in Type 1 Diabetes

Selenium

Only in Schizophrenia

None indexed

Taxa enriched

4 shared

Taxa depleted

5 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Roseburia Lachnospiraceae Blautia

Only in Type 1 Diabetes

Subdoligranulum Eubacterium rectale Prevotella LactobacillusClostridium Clusters IV/XIVaEubacterium eligens Clostridium

Only in Schizophrenia

Coprococcus Saccharomyces cerevisiae Desulfovibrio Veillonellaceae

Host response elevated

1 shared

Shared

Hepcidin

Only in Type 1 Diabetes

ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationFerritinAnti ZnT8 Autoantibodies

Only in Schizophrenia

CRPSCD14IL 6IL-1beta (Interleukin-1 Beta)TNF-alpha (Tumor Necrosis Factor Alpha)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperCeruloplasmin Lipocalin-2 ZonulinAlpha 1 Antitrypsin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Type 1 Diabetes

Treg FunctionGPR43 SCFA SignalingZinc BioavailabilityZinc Metallothionein

Only in Schizophrenia

Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Ecological state

0 shared

Shared

None indexed

Only in Type 1 Diabetes

Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window

Only in Schizophrenia

SCFA DepletionGut Barrier DysfunctionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityGut Barrier DisruptionMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Virulence and functional enzymes

2 shared

Shared

LPS BiosynthesisBeta-Glucuronidase

Only in Type 1 Diabetes

LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine Methyltransferases

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsSiderophore SystemsIndoleamine 2 3 DioxygenaseTryptophanase