Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
12: shared signals

First condition

Second condition

Comparison

Rheumatoid ArthritisandSchizophrenia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

7: Rheumatoid Arthritis references
46: Schizophrenia references
0: shared references

Metals elevated or accumulated

4 shared

Metals depleted or redistributed

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

Vitamin D Nickel

Only in Schizophrenia

Zinc Glutathione (GSH)

Taxa enriched

1 shared

Shared

Enterobacteriaceae

Only in Rheumatoid Arthritis

Prevotella copri Escherichia coli Collinsella

Only in Schizophrenia

Lactobacillus Prevotella Streptococcus VeillonellaSuccinivibrioCandida albicansTrichosporonPurpureocillium Clostridia Betaproteobacteria Prevotellaceae

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Lachnospiraceae Bifidobacterium

Only in Rheumatoid Arthritis

Bacteroides fragilis

Only in Schizophrenia

Roseburia Coprococcus Blautia Saccharomyces cerevisiae Desulfovibrio Veillonellaceae

Host response elevated

2 shared

Shared

Ceruloplasmin Hepcidin

Only in Rheumatoid Arthritis

Calprotectin (S100A8/A9)

Only in Schizophrenia

CRPSCD14IL 6IL-1beta (Interleukin-1 Beta)TNF-alpha (Tumor Necrosis Factor Alpha)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperLipocalin-2 ZonulinAlpha 1 Antitrypsin

Host response depleted

2 shared

Shared

Vitamin D Glutathione (GSH)

Only in Rheumatoid Arthritis

None indexed

Only in Schizophrenia

Total Antioxidant CapacityAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Ecological state

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

Mucosal Origin AutoimmunityBarrier DysfunctionMolecular MimicryTh17 DominanceMetal VitD Bone AxisSoil Food Chain Exposure

Only in Schizophrenia

SCFA DepletionGut Barrier DysfunctionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityGut Barrier DisruptionMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

MetalloproteinasesSiderophoresLPS Biosynthesis Enzymes

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsLPS BiosynthesisSiderophore SystemsBeta-GlucuronidaseIndoleamine 2 3 DioxygenaseTryptophanase