Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
14: shared signals

First condition

Second condition

Comparison

ObesityandGastroesophageal Reflux Disease (GERD)

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Obesity references
16: Gastroesophageal Reflux Disease (GERD) references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Nickel

Only in Obesity

Cadmium Lead Manganese Zinc Iron

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 Metals

Metals depleted or redistributed

2 shared

Taxa enriched

3 shared

Shared

Escherichia coli Enterobacteriaceae Fusobacterium

Only in Obesity

Streptococcus Bacteroides fragilis

Only in Gastroesophageal Reflux Disease (GERD)

Prevotella Pseudomonas Veillonella Leptotrichia Bacteroides Candida albicans Fusobacterium nucleatum Mollicutes Collinsella Eggerthella

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Lachnospiraceae Akkermansia muciniphila Bifidobacterium

Only in Obesity

Roseburia Oscillospiraceae

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Blautia Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Host response elevated

0 shared

Shared

None indexed

Only in Obesity

Hepcidin Calprotectin (S100A8/A9)Transferrin Lipocalin-2 Lactoferrin Ferritin

Only in Gastroesophageal Reflux Disease (GERD)

IL 6IL-8 (Interleukin-8 / CXCL8)NF KappaBTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Obesity

Butyrate Short-Chain Fatty Acids (SCFAs)

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic Cells

Ecological state

0 shared

Shared

None indexed

Only in Obesity

HypoxiaMetal Driven DysbiosisReduced SCFA ProductionIncreased LPSEndotoxemiaIntestinal Permeability IncreaseFermentative Metabolism Acidic MicroenvironmentMetabolic EndotoxemiaReduced Microbial DiversityIncreased Energy HarvestBile Acid DysregulationVirome Depletion

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Virulence and functional enzymes

3 shared

Shared

Nickel-UreaseLPS BiosynthesisBeta-Glucuronidase

Only in Obesity

TMA LyaseSiderophoresNickel HydrogenaseZinc Metalloproteases

Only in Gastroesophageal Reflux Disease (GERD)

NiFe-HydrogenaseArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal Lipases