Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

6%: weighted overlap
7: shared signals

First condition

Second condition

Comparison

Necrotizing EnterocolitisandGastroesophageal Reflux Disease (GERD)

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

19: Necrotizing Enterocolitis references
16: Gastroesophageal Reflux Disease (GERD) references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Necrotizing Enterocolitis

Iron

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 MetalsNickel

Metals depleted or redistributed

1 shared

Shared

Zinc

Only in Necrotizing Enterocolitis

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Glutathione (GSH)Iron Magnesium Calcium

Taxa enriched

1 shared

Shared

Escherichia coli

Only in Necrotizing Enterocolitis

Klebsiella Clostridium perfringens Staphylococcus Klebsiella pneumoniaeClostridium Perfringens (Toxigenic)Sphingomonas Spp.Clostridium Spp. (Obligate Anaerobe Cluster)Bacteroides/Prevotella (Obligate Anaerobe Cluster)Staphylococcus epidermidis Enterococcus

Only in Gastroesophageal Reflux Disease (GERD)

Prevotella Pseudomonas Veillonella Leptotrichia Fusobacterium Enterobacteriaceae Bacteroides Candida albicans Fusobacterium nucleatum Mollicutes Collinsella Eggerthella

Taxa depleted

1 shared

Host response elevated

3 shared

Shared

TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)IL 6

Only in Necrotizing Enterocolitis

Calprotectin (S100A8/A9)Lactoferrin EndogenousPro Inflammatory CytokinesTLR4 ExpressionLPS

Only in Gastroesophageal Reflux Disease (GERD)

IL-8 (Interleukin-8 / CXCL8)NF KappaBTLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Host response depleted

0 shared

Shared

None indexed

Only in Necrotizing Enterocolitis

Zinc Defensins AcetateLactateSecretory IgA

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic CellsGlutathione (GSH)

Ecological state

0 shared

Shared

None indexed

Only in Necrotizing Enterocolitis

Proteobacteria Bloom 2 Weeks Pre DiagnosisVirome Convergence 10 Days Pre OnsetTLR4 Upregulation In Premature EpitheliumBifidobacterium Absence As PreconditionHMO Mediated Colonization ResistanceFeed Forward Barrier DestructionProteobacteria BloomTLR4 Feed Forward LoopVirome ConvergenceImmature BarrierParenteral Iron OverloadBiofilmBile Acid Accumulation ASBT UpregulationMuc2 Depletion Mucosal Barrier FailureObligate Anaerobe Mucosal InvasionGut Brain Axis NDI RiskAntibiotic Driven Richness Nadir Week4

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Virulence and functional enzymes

1 shared

Shared

LPS Biosynthesis

Only in Necrotizing Enterocolitis

SiderophoresAlpha ToxinPerfringolysin OBiofilm Formation Enzymes

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal LipasesBeta-Glucuronidase