Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

16%: weighted overlap
15: shared signals

First condition

Second condition

Comparison

Hashimoto's ThyroiditisandSchizophrenia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

17: Hashimoto's Thyroiditis references
46: Schizophrenia references
0: shared references

Metals elevated or accumulated

3 shared

Shared

Cadmium Lead Copper

Only in Hashimoto's Thyroiditis

Iodine ExcessMercury Nickel

Only in Schizophrenia

Iron Arsenic

Metals depleted or redistributed

1 shared

Taxa enriched

1 shared

Shared

Prevotella

Only in Hashimoto's Thyroiditis

Proteobacteria (Pseudomonadota)Actinobacteria (Actinomycetota)Blautia Dorea Akkermansia muciniphila Bifidobacterium Intestinimonas Turicibacter Klebsiella pneumoniae

Only in Schizophrenia

Lactobacillus Enterobacteriaceae Streptococcus VeillonellaSuccinivibrioCandida albicansTrichosporonPurpureocillium Clostridia Betaproteobacteria Prevotellaceae

Taxa depleted

5 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Roseburia Lachnospiraceae Coprococcus

Only in Hashimoto's Thyroiditis

Lactobacillus Akkermansia muciniphila

Only in Schizophrenia

Blautia Saccharomyces cerevisiae Desulfovibrio Veillonellaceae

Host response elevated

2 shared

Shared

Hepcidin Ceruloplasmin

Only in Hashimoto's Thyroiditis

Calprotectin (S100A8/A9)Advanced Glycation End Products

Only in Schizophrenia

CRPSCD14IL 6IL-1beta (Interleukin-1 Beta)TNF-alpha (Tumor Necrosis Factor Alpha)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperLipocalin-2 ZonulinAlpha 1 Antitrypsin

Host response depleted

0 shared

Shared

None indexed

Only in Hashimoto's Thyroiditis

Selenium Dependent GPxSelenium Dependent TrxRButyrateValeric AcidGlutathione PeroxidaseThioredoxin ReductaseSelenium Dependent Selenoproteins

Only in Schizophrenia

Glutathione (GSH)Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Ecological state

2 shared

Shared

Th17 Treg ImbalanceSCFA Depletion

Only in Hashimoto's Thyroiditis

Molecular MimicryIodine Driven DysbiosisTryptophan Metabolism DisruptionBile Acid DysmetabolismButyrate DepletionOxidative Stress

Only in Schizophrenia

Gut Barrier DysfunctionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityGut Barrier DisruptionMicroglial ActivationVirome Dysbiosis

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Hashimoto's Thyroiditis

Bacterial DeiodinasesLPS EndotoxinIDO1 Kynurenine AhR PathwayThyroid Peroxidase Mimics

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsLPS BiosynthesisSiderophore SystemsIndoleamine 2 3 DioxygenaseTryptophanase