Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

17%: weighted overlap
17: shared signals

First condition

Second condition

Comparison

Gastroesophageal Reflux Disease (GERD)andType 2 Diabetes

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

16: Gastroesophageal Reflux Disease (GERD) references
30: Type 2 Diabetes references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Nickel

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 Metals

Only in Type 2 Diabetes

Iron Cadmium Arsenic Lead

Metals depleted or redistributed

3 shared

Taxa enriched

4 shared

Shared

Prevotella Enterobacteriaceae Escherichia coli Candida albicans

Only in Gastroesophageal Reflux Disease (GERD)

Pseudomonas Veillonella Leptotrichia Fusobacterium Bacteroides Fusobacterium nucleatum Mollicutes Collinsella Eggerthella

Only in Type 2 Diabetes

Streptococcus Enterococcus Helicobacter pylori Campylobacter jejuni

Taxa depleted

5 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Blautia Lachnospiraceae Akkermansia muciniphila

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Only in Type 2 Diabetes

Ruminococcus Bacteroides fragilis Roseburia

Host response elevated

2 shared

Shared

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)

Only in Gastroesophageal Reflux Disease (GERD)

IL-8 (Interleukin-8 / CXCL8)NF KappaBIL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Only in Type 2 Diabetes

Lipopolysaccharide HepcidinInflammatory CytokinesFerritin Ceruloplasmin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic Cells

Only in Type 2 Diabetes

ButyratePropionateAcetateBile AcidsZinc Chromium Manganese Magnesium

Ecological state

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Only in Type 2 Diabetes

DysbiosisSCFA DepletionLPS ElevationBile Acid DysmetabolismImpaired Intestinal BarrierLipid PeroxidationReduced Microbial DiversityEndotoxemiaGut Barrier DisruptionBile Acid DysregulationIron Overload Oxidative StressFungal Overgrowth

Virulence and functional enzymes

1 shared

Shared

Nickel-Urease

Only in Gastroesophageal Reflux Disease (GERD)

NiFe-HydrogenaseLPS BiosynthesisArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal LipasesBeta-Glucuronidase

Only in Type 2 Diabetes

LipopolysaccharideCholine TMA LyaseBile Acid DehydrataseCarbohydrate Fermentation EnzymesSiderophoresLPS Biosynthesis EnzymesTMA Lyase CutC CutD