Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

14%: weighted overlap
12: shared signals

First condition

Second condition

Comparison

Gastroesophageal Reflux Disease (GERD)andGraves' Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

16: Gastroesophageal Reflux Disease (GERD) references
22: Graves' Disease references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 MetalsNickel

Only in Graves' Disease

LeadIodine DysregulatedIron Cadmium Mercury

Metals depleted or redistributed

2 shared

Taxa enriched

5 shared

Shared

Prevotella Veillonella Enterobacteriaceae Escherichia coli Collinsella

Only in Gastroesophageal Reflux Disease (GERD)

Pseudomonas Leptotrichia Fusobacterium Bacteroides Candida albicans Fusobacterium nucleatum Mollicutes Eggerthella

Only in Graves' Disease

Bacteroides fragilis Streptococcus Lactobacillus Bifidobacterium Desulfovibrio

Taxa depleted

4 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Lachnospiraceae Akkermansia muciniphila

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Blautia Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Only in Graves' Disease

Phascolarctobacterium Roseburia Dialister Butyricimonas Lachnospira

Host response elevated

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

IL 6IL-8 (Interleukin-8 / CXCL8)NF KappaBTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Only in Graves' Disease

Hepcidin Transferrin Lipocalin-2

Host response depleted

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic CellsGlutathione (GSH)

Only in Graves' Disease

SelenoproteinsGlutathione PeroxidaseThioredoxin ReductaseDeiodinases

Ecological state

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Only in Graves' Disease

Intestinal PermeabilityTh17 Treg ImbalanceMolecular Mimicry Estrogen RecirculationSCFA DeficiencyLPS TranslocationBidirectional Gut Thyroid Axis

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseLPS BiosynthesisArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal Lipases

Only in Graves' Disease

SiderophoresLPSThyroid Peroxidase Mimicry AntigensLPS Endotoxin