Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

7%: weighted overlap
7: shared signals

First condition

Second condition

Comparison

Alzheimer's DiseaseandNecrotizing Enterocolitis

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Alzheimer's Disease references
19: Necrotizing Enterocolitis references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Iron

Only in Alzheimer's Disease

Lead Cadmium Arsenic Manganese Copper Mercury AluminumZinc In PlaquesNickel

Only in Necrotizing Enterocolitis

None indexed

Metals depleted or redistributed

1 shared

Shared

Zinc

Only in Alzheimer's Disease

Copper SeleniumCopper BrainZinc SerumGlutathione (GSH)

Only in Necrotizing Enterocolitis

None indexed

Taxa enriched

2 shared

Shared

Escherichia coli Klebsiella pneumoniae

Only in Alzheimer's Disease

Helicobacter pylori Bacteroides fragilis Prevotella Akkermansia muciniphila Candida albicans

Only in Necrotizing Enterocolitis

Klebsiella Clostridium perfringens StaphylococcusClostridium Perfringens (Toxigenic)Sphingomonas Spp.Clostridium Spp. (Obligate Anaerobe Cluster)Bacteroides/Prevotella (Obligate Anaerobe Cluster)Staphylococcus epidermidis Enterococcus

Taxa depleted

1 shared

Host response elevated

1 shared

Shared

Calprotectin (S100A8/A9)

Only in Alzheimer's Disease

Hepcidin Lipocalin-2Proinflammatory CytokinesTransferrin Receptor AlteredFerritin AlteredTREM2

Only in Necrotizing Enterocolitis

Lactoferrin EndogenousPro Inflammatory CytokinesTLR4 ExpressionLPSTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)IL 6

Host response depleted

0 shared

Shared

None indexed

Only in Alzheimer's Disease

Glutathione (GSH)ButyratePropionateIndole DerivativesTryptophan MetabolitesSelenoproteinsCeruloplasmin Function

Only in Necrotizing Enterocolitis

Zinc Defensins AcetateLactateSecretory IgA

Ecological state

0 shared

Shared

None indexed

Only in Alzheimer's Disease

Hypoxia DysbiosisBarrier DysfunctionNeuroinflammationAmyloid SeedingMicroglial ActivationLPS TranslocationBlood Brain Barrier DisruptionAmyloid Cross SeedingLPS EndotoxemiaSCFA DepletionTMAO ElevationFerroptosisEpigenetic Latency

Only in Necrotizing Enterocolitis

Proteobacteria Bloom 2 Weeks Pre DiagnosisVirome Convergence 10 Days Pre OnsetTLR4 Upregulation In Premature EpitheliumBifidobacterium Absence As PreconditionHMO Mediated Colonization ResistanceFeed Forward Barrier DestructionProteobacteria BloomTLR4 Feed Forward LoopVirome ConvergenceImmature BarrierParenteral Iron OverloadBiofilmBile Acid Accumulation ASBT UpregulationMuc2 Depletion Mucosal Barrier FailureObligate Anaerobe Mucosal InvasionGut Brain Axis NDI RiskAntibiotic Driven Richness Nadir Week4

Virulence and functional enzymes

1 shared

Shared

Siderophores

Only in Alzheimer's Disease

Curli FibersLipopolysaccharideBacterial AmyloidsUreaseMetalloproteasesNickel-UreaseCurli AmyloidLPSBeta-Glucuronidase

Only in Necrotizing Enterocolitis

LPS BiosynthesisAlpha ToxinPerfringolysin OBiofilm Formation Enzymes