Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

18%: weighted overlap
18: shared signals

First condition

Second condition

Comparison

ObesityandColorectal Cancer

2 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Obesity references
36: Colorectal Cancer references
2: shared references

Metals elevated or accumulated

5 shared

Metals depleted or redistributed

0 shared

Shared

None indexed

Only in Obesity

Glutathione (GSH)Magnesium Barium Vanadium Titanium

Only in Colorectal Cancer

Butyrate Zinc Selenium Manganese

Taxa enriched

2 shared

Shared

Escherichia coli Bacteroides fragilis

Only in Obesity

Streptococcus Enterobacteriaceae Fusobacterium

Only in Colorectal Cancer

Fusobacterium nucleatum Fusobacterium varium Parvimonas micra Peptostreptococcus stomatis Clostridium symbiosum Porphyromonas gingivalis Akkermansia muciniphila Candida albicans Peptostreptococcus anaerobius Enterococcus faecalis Streptococcus gallolyticus Saccharomyces cerevisiae

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Roseburia Lachnospiraceae Bifidobacterium

Only in Obesity

Akkermansia muciniphila Oscillospiraceae

Only in Colorectal Cancer

Prevotella copri Ruminococcus albus Dialister Lactobacillus Ruminococcus

Host response elevated

3 shared

Shared

Hepcidin Calprotectin (S100A8/A9)Lipocalin-2

Only in Obesity

Transferrin Lactoferrin Ferritin

Only in Colorectal Cancer

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)Lipopolysaccharide

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Obesity

Butyrate Short-Chain Fatty Acids (SCFAs)

Only in Colorectal Cancer

IL-10 (Interleukin-10)IgATreg CellsSelenium Dependent Glutathione Peroxidase

Ecological state

1 shared

Shared

Hypoxia

Only in Obesity

Metal Driven DysbiosisReduced SCFA ProductionIncreased LPSEndotoxemiaIntestinal Permeability IncreaseFermentative Metabolism Acidic MicroenvironmentMetabolic EndotoxemiaReduced Microbial DiversityIncreased Energy HarvestBile Acid DysregulationVirome Depletion

Only in Colorectal Cancer

BiofilmSecondary Bile Acid AccumulationFermentative Acidic MicroenvironmentEpithelial Barrier DisruptionColonic Serotonin DepletionAnaerobic DominanceSecondary Bile Acid ExcessSCFA DepletionWarburg EffectCross Kingdom DysbiosisVirome Network Disruption

Virulence and functional enzymes

2 shared

Shared

Siderophores Beta-Glucuronidase

Only in Obesity

TMA LyaseNickel-UreaseNickel HydrogenaseZinc MetalloproteasesLPS Biosynthesis

Only in Colorectal Cancer

FadAFap2LPS TLR4BFT ToxinColibactin PksUrease Glyoxalase IBFT Zinc MetalloproteaseColibactin GenotoxinFadA AdhesinFap2 LectinNAD(P)H Oxidase