Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

13%: weighted overlap
13: shared signals

First condition

Second condition

Comparison

DepressionandGastroesophageal Reflux Disease (GERD)

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

38: Depression references
16: Gastroesophageal Reflux Disease (GERD) references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Depression

Cadmium Lead Mercury Copper

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 MetalsNickel

Metals depleted or redistributed

3 shared

Taxa enriched

4 shared

Shared

Candida albicans Escherichia coli Eggerthella Enterobacteriaceae

Only in Depression

Clostridium Bacteroides fragilis Flavonifractor

Only in Gastroesophageal Reflux Disease (GERD)

Prevotella Pseudomonas Veillonella Leptotrichia Fusobacterium Bacteroides Fusobacterium nucleatum Mollicutes Collinsella

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Lachnospiraceae

Only in Depression

Prevotella Coprococcus Dialister Lactobacillus

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Blautia Akkermansia muciniphila Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Host response elevated

0 shared

Shared

None indexed

Only in Depression

Hepcidin Calprotectin (S100A8/A9)Pro Inflammatory CytokinesCeruloplasmin Ferritin

Only in Gastroesophageal Reflux Disease (GERD)

IL 6IL-8 (Interleukin-8 / CXCL8)NF KappaBTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Depression

Zinc Magnesium Iron SeleniumGlutathione Peroxidase

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic Cells

Ecological state

0 shared

Shared

None indexed

Only in Depression

DysbiosisLeaky GutIntestinal Permeability EndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOSCFA DepletionHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Virulence and functional enzymes

2 shared

Shared

Beta-GlucuronidaseLPS Biosynthesis

Only in Depression

TryptophanasePro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal Lipases