Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 19%
- weighted overlap
- 19
- shared signals
Comparison
DepressionandAlzheimer's Disease
9 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 38
- Depression references
- 31
- Alzheimer's Disease references
- 9
- shared references
Metals depleted or redistributed
2 sharedTaxa enriched
3 sharedShared
Only in Depression
Only in Alzheimer's Disease
Taxa depleted
2 sharedShared
Only in Depression
Only in Alzheimer's Disease
Host response elevated
2 sharedShared
Only in Depression
Only in Alzheimer's Disease
Host response depleted
1 sharedEcological state
4 sharedShared
Only in Depression
Leaky GutIntestinal PermeabilityEndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis Hyperactivation
Only in Alzheimer's Disease
HypoxiaBarrier DysfunctionAmyloid SeedingMicroglial ActivationLPS TranslocationAmyloid Cross SeedingLPS EndotoxemiaTMAO ElevationFerroptosisEpigenetic Latency
Virulence and functional enzymes
1 sharedShared
Only in Depression
TryptophanaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli
Only in Alzheimer's Disease
Curli FibersLipopolysaccharideBacterial AmyloidsSiderophoresUreaseMetalloproteasesNickel-UreaseCurli AmyloidLPS