Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

18%: weighted overlap
18: shared signals

First condition

Second condition

Comparison

Colorectal CancerandObesity

2 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

36: Colorectal Cancer references
31: Obesity references
2: shared references

Metals elevated or accumulated

5 shared

Metals depleted or redistributed

0 shared

Shared

None indexed

Only in Colorectal Cancer

Butyrate Zinc Selenium Manganese

Only in Obesity

Glutathione (GSH)Magnesium Barium Vanadium Titanium

Taxa enriched

2 shared

Shared

Bacteroides fragilis Escherichia coli

Only in Colorectal Cancer

Fusobacterium nucleatum Fusobacterium varium Parvimonas micra Peptostreptococcus stomatis Clostridium symbiosum Porphyromonas gingivalis Akkermansia muciniphila Candida albicans Peptostreptococcus anaerobius Enterococcus faecalis Streptococcus gallolyticus Saccharomyces cerevisiae

Only in Obesity

Streptococcus Enterobacteriaceae Fusobacterium

Taxa depleted

4 shared

Shared

Lachnospiraceae Faecalibacterium prausnitzii Roseburia Bifidobacterium

Only in Colorectal Cancer

Prevotella copri Ruminococcus albus Dialister Lactobacillus Ruminococcus

Only in Obesity

Akkermansia muciniphila Oscillospiraceae

Host response elevated

3 shared

Shared

Calprotectin (S100A8/A9)Hepcidin Lipocalin-2

Only in Colorectal Cancer

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)Lipopolysaccharide

Only in Obesity

Transferrin Lactoferrin Ferritin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Colorectal Cancer

IL-10 (Interleukin-10)IgATreg CellsSelenium Dependent Glutathione Peroxidase

Only in Obesity

Butyrate Short-Chain Fatty Acids (SCFAs)

Ecological state

1 shared

Shared

Hypoxia

Only in Colorectal Cancer

BiofilmSecondary Bile Acid AccumulationFermentative Acidic MicroenvironmentEpithelial Barrier DisruptionColonic Serotonin DepletionAnaerobic DominanceSecondary Bile Acid ExcessSCFA DepletionWarburg EffectCross Kingdom DysbiosisVirome Network Disruption

Only in Obesity

Metal Driven DysbiosisReduced SCFA ProductionIncreased LPSEndotoxemiaIntestinal Permeability IncreaseFermentative Metabolism Acidic MicroenvironmentMetabolic EndotoxemiaReduced Microbial DiversityIncreased Energy HarvestBile Acid DysregulationVirome Depletion

Virulence and functional enzymes

2 shared

Shared

Siderophores Beta-Glucuronidase

Only in Colorectal Cancer

FadAFap2LPS TLR4BFT ToxinColibactin PksUrease Glyoxalase IBFT Zinc MetalloproteaseColibactin GenotoxinFadA AdhesinFap2 LectinNAD(P)H Oxidase

Only in Obesity

TMA LyaseNickel-UreaseNickel HydrogenaseZinc MetalloproteasesLPS Biosynthesis