Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

17%: weighted overlap
20: shared signals

First condition

Second condition

Comparison

Colorectal CancerandLong COVID

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

36: Colorectal Cancer references
18: Long COVID references
0: shared references

Metals elevated or accumulated

2 shared

Metals depleted or redistributed

1 shared

Shared

Selenium

Only in Colorectal Cancer

Butyrate Zinc Manganese

Only in Long COVID

Iron Copper Nickel Glutathione (GSH)

Taxa enriched

3 shared

Taxa depleted

5 shared

Shared

Lachnospiraceae Faecalibacterium prausnitzii Roseburia Bifidobacterium Lactobacillus

Only in Colorectal Cancer

Prevotella copri Ruminococcus albus Dialister Ruminococcus

Only in Long COVID

Akkermansia muciniphila

Host response elevated

5 shared

Shared

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)Calprotectin (S100A8/A9)Hepcidin

Only in Colorectal Cancer

Lipopolysaccharide Lipocalin-2

Only in Long COVID

IFN-gamma (Interferon Gamma)LPS In CirculationPD 1 On CD8TIM 3 On CD8AutoantibodiesZinc In Secretions

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Colorectal Cancer

IL-10 (Interleukin-10)IgATreg CellsSelenium Dependent Glutathione Peroxidase

Only in Long COVID

Regulatory T CellsNK Cell FunctionMemory B CellsSIgAButyrate SeleniumIron In Tissues

Ecological state

1 shared

Shared

SCFA Depletion

Only in Colorectal Cancer

Hypoxia BiofilmSecondary Bile Acid AccumulationFermentative Acidic MicroenvironmentEpithelial Barrier DisruptionColonic Serotonin DepletionAnaerobic DominanceSecondary Bile Acid ExcessWarburg EffectCross Kingdom DysbiosisVirome Network Disruption

Only in Long COVID

Self Perpetuating Dysbiosis LoopAnaerobe To Aerobe ShiftSCFA CollapseBacterial Translocation EndotoxemiaGut Lung Axis DisruptionGut Brain Axis DisruptionTryptophan AhR DysmetabolismVirome Co DysbiosisMulti Kingdom DysbiosisNon Linear Recovery TrajectoryStrain Level Diversity CollapseEstrobolome DysfunctionUremic Metabolite AccumulationHypoxia CellularAerobe BloomBarrier DysfunctionBacterial TranslocationMulti Kingdom Co DysbiosisNon Linear Recovery

Virulence and functional enzymes

2 shared

Shared

Siderophores Beta-Glucuronidase

Only in Colorectal Cancer

FadAFap2LPS TLR4BFT ToxinColibactin PksUrease Glyoxalase IBFT Zinc MetalloproteaseColibactin GenotoxinFadA AdhesinFap2 LectinNAD(P)H Oxidase

Only in Long COVID

LPS Synthesis TransportAdhesion Invasion FactorsBile Salt Hydrolase (BSH)Polysaccharide DegradationLPS Biosynthesis EnzymesBeta Lactamases