Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

18%: weighted overlap
18: shared signals

First condition

Second condition

Comparison

Colorectal CancerandDepression

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

36: Colorectal Cancer references
38: Depression references
0: shared references

Metals elevated or accumulated

3 shared

Metals depleted or redistributed

2 shared

Shared

Zinc Selenium

Only in Colorectal Cancer

Butyrate Manganese

Only in Depression

Magnesium Iron

Taxa enriched

3 shared

Shared

Bacteroides fragilis Escherichia coli Candida albicans

Only in Colorectal Cancer

Fusobacterium nucleatum Fusobacterium varium Parvimonas micra Peptostreptococcus stomatis Clostridium symbiosum Porphyromonas gingivalis Akkermansia muciniphila Peptostreptococcus anaerobius Enterococcus faecalis Streptococcus gallolyticus Saccharomyces cerevisiae

Only in Depression

Clostridium Eggerthella Enterobacteriaceae Flavonifractor

Taxa depleted

5 shared

Shared

Lachnospiraceae Faecalibacterium prausnitzii Dialister Bifidobacterium Lactobacillus

Only in Colorectal Cancer

Roseburia Prevotella copri Ruminococcus albus Ruminococcus

Only in Depression

Prevotella Coprococcus

Host response elevated

2 shared

Shared

Calprotectin (S100A8/A9)Hepcidin

Only in Colorectal Cancer

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)Lipopolysaccharide Lipocalin-2

Only in Depression

Pro Inflammatory CytokinesCeruloplasmin Ferritin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Colorectal Cancer

IL-10 (Interleukin-10)IgATreg CellsSelenium Dependent Glutathione Peroxidase

Only in Depression

Zinc Magnesium Iron SeleniumGlutathione Peroxidase

Ecological state

1 shared

Shared

SCFA Depletion

Only in Colorectal Cancer

Hypoxia BiofilmSecondary Bile Acid AccumulationFermentative Acidic MicroenvironmentEpithelial Barrier DisruptionColonic Serotonin DepletionAnaerobic DominanceSecondary Bile Acid ExcessWarburg EffectCross Kingdom DysbiosisVirome Network Disruption

Only in Depression

DysbiosisLeaky GutIntestinal Permeability EndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Colorectal Cancer

FadAFap2LPS TLR4BFT ToxinColibactin PksSiderophores Urease Glyoxalase IBFT Zinc MetalloproteaseColibactin GenotoxinFadA AdhesinFap2 LectinNAD(P)H Oxidase

Only in Depression

TryptophanaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli