Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

21%: weighted overlap
22: shared signals

First condition

Second condition

Comparison

Colorectal CancerandCardiovascular Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

36: Colorectal Cancer references
24: Cardiovascular Disease references
0: shared references

Metals elevated or accumulated

5 shared

Shared

Iron Cadmium Lead Copper Nickel

Only in Colorectal Cancer

Zinc Arsenic Chromium

Only in Cardiovascular Disease

None indexed

Metals depleted or redistributed

2 shared

Taxa enriched

4 shared

Shared

Bacteroides fragilis Escherichia coli Porphyromonas gingivalis Candida albicans

Only in Colorectal Cancer

Fusobacterium nucleatum Fusobacterium varium Parvimonas micra Peptostreptococcus stomatis Clostridium symbiosum Akkermansia muciniphila Peptostreptococcus anaerobius Enterococcus faecalis Streptococcus gallolyticus Saccharomyces cerevisiae

Only in Cardiovascular Disease

Enterobacteriaceae Streptococcus Eggerthella lenta Ruminococcus gnavus Malassezia

Taxa depleted

3 shared

Shared

Lachnospiraceae Faecalibacterium prausnitzii Roseburia

Only in Colorectal Cancer

Prevotella copri Ruminococcus albus Dialister Bifidobacterium Lactobacillus Ruminococcus

Only in Cardiovascular Disease

Allisonella Clostridium Clostridiales Mycobiome

Host response elevated

3 shared

Shared

Calprotectin (S100A8/A9)Hepcidin Lipocalin-2

Only in Colorectal Cancer

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)Lipopolysaccharide

Only in Cardiovascular Disease

TransferrinLipopolysaccharide LPSCeruloplasmin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Colorectal Cancer

IL-10 (Interleukin-10)IgATreg CellsSelenium Dependent Glutathione Peroxidase

Only in Cardiovascular Disease

ButyratePropionateAcetate SeleniumSelenoproteinsGlutathione Peroxidase

Ecological state

2 shared

Shared

Hypoxia Biofilm

Only in Colorectal Cancer

Secondary Bile Acid AccumulationFermentative Acidic MicroenvironmentEpithelial Barrier DisruptionColonic Serotonin DepletionAnaerobic DominanceSecondary Bile Acid ExcessSCFA DepletionWarburg EffectCross Kingdom DysbiosisVirome Network Disruption

Only in Cardiovascular Disease

TMAO Production DominanceLPS EndotoxemiaIndoxyl Sulfate AccumulationReduced Butyrate EcosystemFunctional ShieldingOral To Gut TranslocationEndotoxemiaOral Gut TranslocationTMAO AccumulationFungal Bacterial Co Dysbiosis

Virulence and functional enzymes

2 shared

Shared

Siderophores Beta-Glucuronidase

Only in Colorectal Cancer

FadAFap2LPS TLR4BFT ToxinColibactin PksUrease Glyoxalase IBFT Zinc MetalloproteaseColibactin GenotoxinFadA AdhesinFap2 LectinNAD(P)H Oxidase

Only in Cardiovascular Disease

TMA Lyase CutC/DLipopolysaccharide LPS BiosynthesisSiderophores Enterobactin YersiniabactinTryptophanaseIndole ProductionHSP60TMA Lyase CutC CutDLPS Biosynthesis Enzymes