Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
19: shared signals

First condition

Second condition

Comparison

Colorectal CancerandAutism Spectrum Disorder

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

36: Colorectal Cancer references
32: Autism Spectrum Disorder references
0: shared references

Metals elevated or accumulated

5 shared

Metals depleted or redistributed

2 shared

Shared

Zinc Selenium

Only in Colorectal Cancer

Butyrate Manganese

Only in Autism Spectrum Disorder

Iron Glutathione (GSH)

Taxa enriched

0 shared

Shared

None indexed

Only in Colorectal Cancer

Fusobacterium nucleatum Fusobacterium varium Bacteroides fragilis Parvimonas micra Peptostreptococcus stomatis Escherichia coli Clostridium symbiosum Porphyromonas gingivalis Akkermansia muciniphila Candida albicans Peptostreptococcus anaerobius Enterococcus faecalis Streptococcus gallolyticus Saccharomyces cerevisiae

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium CoprostanoligenesDesulfovibrio

Taxa depleted

4 shared

Shared

Lachnospiraceae Faecalibacterium prausnitzii Bifidobacterium Lactobacillus

Only in Colorectal Cancer

Roseburia Prevotella copri Ruminococcus albus Dialister Ruminococcus

Only in Autism Spectrum Disorder

Coprococcus

Host response elevated

5 shared

Shared

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)Calprotectin (S100A8/A9)Hepcidin Lipocalin-2

Only in Colorectal Cancer

IL-1beta (Interleukin-1 Beta)Lipopolysaccharide

Only in Autism Spectrum Disorder

Lactoferrin TransferrinIL 1IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Host response depleted

2 shared

Shared

IL-10 (Interleukin-10)Glutathione (GSH)

Only in Colorectal Cancer

IgATreg CellsSelenium Dependent Glutathione Peroxidase

Only in Autism Spectrum Disorder

SulfateZinc TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Ecological state

0 shared

Shared

None indexed

Only in Colorectal Cancer

Hypoxia BiofilmSecondary Bile Acid AccumulationFermentative Acidic MicroenvironmentEpithelial Barrier DisruptionColonic Serotonin DepletionAnaerobic DominanceSecondary Bile Acid ExcessSCFA DepletionWarburg EffectCross Kingdom DysbiosisVirome Network Disruption

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Colorectal Cancer

FadAFap2LPS TLR4BFT ToxinColibactin PksSiderophores Urease Glyoxalase IBFT Zinc MetalloproteaseColibactin GenotoxinFadA AdhesinFap2 LectinNAD(P)H Oxidase

Only in Autism Spectrum Disorder

ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production