Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

21%: weighted overlap
22: shared signals

First condition

Second condition

Comparison

Cardiovascular DiseaseandColorectal Cancer

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

24: Cardiovascular Disease references
36: Colorectal Cancer references
0: shared references

Metals elevated or accumulated

5 shared

Shared

Nickel Lead Cadmium Iron Copper

Only in Cardiovascular Disease

None indexed

Only in Colorectal Cancer

Zinc Arsenic Chromium

Metals depleted or redistributed

2 shared

Taxa enriched

4 shared

Shared

Escherichia coli Bacteroides fragilis Porphyromonas gingivalis Candida albicans

Only in Cardiovascular Disease

Enterobacteriaceae Streptococcus Eggerthella lenta Ruminococcus gnavus Malassezia

Only in Colorectal Cancer

Fusobacterium nucleatum Fusobacterium varium Parvimonas micra Peptostreptococcus stomatis Clostridium symbiosum Akkermansia muciniphila Peptostreptococcus anaerobius Enterococcus faecalis Streptococcus gallolyticus Saccharomyces cerevisiae

Taxa depleted

3 shared

Shared

Roseburia Faecalibacterium prausnitzii Lachnospiraceae

Only in Cardiovascular Disease

Allisonella Clostridium Clostridiales Mycobiome

Only in Colorectal Cancer

Prevotella copri Ruminococcus albus Dialister Bifidobacterium Lactobacillus Ruminococcus

Host response elevated

3 shared

Shared

Calprotectin (S100A8/A9)Hepcidin Lipocalin-2

Only in Cardiovascular Disease

TransferrinLipopolysaccharide LPSCeruloplasmin

Only in Colorectal Cancer

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)Lipopolysaccharide

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Cardiovascular Disease

ButyratePropionateAcetate SeleniumSelenoproteinsGlutathione Peroxidase

Only in Colorectal Cancer

IL-10 (Interleukin-10)IgATreg CellsSelenium Dependent Glutathione Peroxidase

Ecological state

2 shared

Shared

Hypoxia Biofilm

Only in Cardiovascular Disease

TMAO Production DominanceLPS EndotoxemiaIndoxyl Sulfate AccumulationReduced Butyrate EcosystemFunctional ShieldingOral To Gut TranslocationEndotoxemiaOral Gut TranslocationTMAO AccumulationFungal Bacterial Co Dysbiosis

Only in Colorectal Cancer

Secondary Bile Acid AccumulationFermentative Acidic MicroenvironmentEpithelial Barrier DisruptionColonic Serotonin DepletionAnaerobic DominanceSecondary Bile Acid ExcessSCFA DepletionWarburg EffectCross Kingdom DysbiosisVirome Network Disruption

Virulence and functional enzymes

2 shared

Shared

Beta-Glucuronidase Siderophores

Only in Cardiovascular Disease

TMA Lyase CutC/DLipopolysaccharide LPS BiosynthesisSiderophores Enterobactin YersiniabactinTryptophanaseIndole ProductionHSP60TMA Lyase CutC CutDLPS Biosynthesis Enzymes

Only in Colorectal Cancer

FadAFap2LPS TLR4BFT ToxinColibactin PksUrease Glyoxalase IBFT Zinc MetalloproteaseColibactin GenotoxinFadA AdhesinFap2 LectinNAD(P)H Oxidase