Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

9%: weighted overlap
8: shared signals

First condition

Second condition

Comparison

Alzheimer's DiseaseandPremenstrual Dysphoric Disorder

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Alzheimer's Disease references
6: Premenstrual Dysphoric Disorder references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Copper

Only in Alzheimer's Disease

Lead Cadmium Arsenic Manganese Iron Mercury AluminumZinc In PlaquesNickel

Only in Premenstrual Dysphoric Disorder

None indexed

Metals depleted or redistributed

1 shared

Taxa enriched

1 shared

Shared

Escherichia coli

Only in Alzheimer's Disease

Helicobacter pylori Klebsiella pneumoniae Bacteroides fragilis Prevotella Akkermansia muciniphila Candida albicans

Only in Premenstrual Dysphoric Disorder

Anaerotaenia

Taxa depleted

2 shared

Shared

Blautia Faecalibacterium prausnitzii

Only in Alzheimer's Disease

Saccharomyces Lachnospiraceae Ruminococcus Roseburia Eubacterium rectale Bacteroides

Only in Premenstrual Dysphoric Disorder

Butyricicoccus Megasphaera Parabacteroides

Host response elevated

0 shared

Shared

None indexed

Only in Alzheimer's Disease

Hepcidin Lipocalin-2 Calprotectin (S100A8/A9)Proinflammatory CytokinesTransferrin Receptor AlteredFerritin AlteredTREM2

Only in Premenstrual Dysphoric Disorder

IL-8 (Interleukin-8 / CXCL8)TNF-alpha (Tumor Necrosis Factor Alpha)Pro Inflammatory CytokinesCopper Zinc Ratio

Host response depleted

1 shared

Shared

Butyrate

Only in Alzheimer's Disease

Glutathione (GSH)PropionateIndole DerivativesTryptophan MetabolitesSelenoproteinsCeruloplasmin Function

Only in Premenstrual Dysphoric Disorder

Magnesium Serotonin GABA (Gamma-Aminobutyric Acid)Allopregnanolone Sensitivity

Ecological state

1 shared

Shared

SCFA Depletion

Only in Alzheimer's Disease

Hypoxia DysbiosisBarrier DysfunctionNeuroinflammationAmyloid SeedingMicroglial ActivationLPS TranslocationBlood Brain Barrier DisruptionAmyloid Cross SeedingLPS EndotoxemiaTMAO ElevationFerroptosisEpigenetic Latency

Only in Premenstrual Dysphoric Disorder

Tryptophan Kynurenine ShuntingEstrobolome DysfunctionGABA A Receptor ModulationLuteal Phase InflammationBeta Glucuronidase DysregulationEstrogen RecirculationBeta Glucuronidase ActivityCircadian Rhythm DisruptionMelatonin Amplitude Reduction

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Alzheimer's Disease

Curli FibersLipopolysaccharideBacterial AmyloidsSiderophores UreaseMetalloproteasesNickel-UreaseCurli AmyloidLPS

Only in Premenstrual Dysphoric Disorder

TryptophanaseIDO UpregulationLPS BiosynthesisIndoleamine 2 3 Dioxygenase