Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

16%: weighted overlap
18: shared signals

First condition

Second condition

Comparison

Alzheimer's DiseaseandLong COVID

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Alzheimer's Disease references
18: Long COVID references
0: shared references

Metals elevated or accumulated

1 shared

Metals depleted or redistributed

3 shared

Shared

Copper Selenium Glutathione (GSH)

Only in Alzheimer's Disease

ZincCopper BrainZinc Serum

Only in Long COVID

Iron Nickel

Taxa enriched

3 shared

Shared

Escherichia coli Klebsiella pneumoniae Candida albicans

Only in Alzheimer's Disease

Helicobacter pylori Bacteroides fragilis Prevotella Akkermansia muciniphila

Only in Long COVID

Enterobacteriaceae Streptococcus Enterococcus Veillonella Fusobacterium nucleatum Aspergillus

Taxa depleted

3 shared

Shared

Lachnospiraceae Roseburia Faecalibacterium prausnitzii

Only in Alzheimer's Disease

Saccharomyces Ruminococcus Blautia Eubacterium rectale Bacteroides

Only in Long COVID

Bifidobacterium Lactobacillus Akkermansia muciniphila

Host response elevated

2 shared

Shared

Hepcidin Calprotectin (S100A8/A9)

Only in Alzheimer's Disease

Lipocalin-2Proinflammatory CytokinesTransferrin Receptor AlteredFerritin AlteredTREM2

Only in Long COVID

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)IFN-gamma (Interferon Gamma)LPS In CirculationPD 1 On CD8TIM 3 On CD8AutoantibodiesZinc In Secretions

Host response depleted

2 shared

Shared

Glutathione (GSH)Butyrate

Only in Alzheimer's Disease

PropionateIndole DerivativesTryptophan MetabolitesSelenoproteinsCeruloplasmin Function

Only in Long COVID

Regulatory T CellsNK Cell FunctionMemory B CellsSIgASeleniumIron In Tissues

Ecological state

2 shared

Shared

Barrier DysfunctionSCFA Depletion

Only in Alzheimer's Disease

Hypoxia Dysbiosis NeuroinflammationAmyloid SeedingMicroglial ActivationLPS TranslocationBlood Brain Barrier DisruptionAmyloid Cross SeedingLPS EndotoxemiaTMAO ElevationFerroptosisEpigenetic Latency

Only in Long COVID

Self Perpetuating Dysbiosis LoopAnaerobe To Aerobe ShiftSCFA CollapseBacterial Translocation EndotoxemiaGut Lung Axis DisruptionGut Brain Axis DisruptionTryptophan AhR DysmetabolismVirome Co DysbiosisMulti Kingdom DysbiosisNon Linear Recovery TrajectoryStrain Level Diversity CollapseEstrobolome DysfunctionUremic Metabolite AccumulationHypoxia CellularAerobe BloomBacterial TranslocationMulti Kingdom Co DysbiosisNon Linear Recovery

Virulence and functional enzymes

2 shared

Shared

Siderophores Beta-Glucuronidase

Only in Alzheimer's Disease

Curli FibersLipopolysaccharideBacterial AmyloidsUreaseMetalloproteasesNickel-UreaseCurli AmyloidLPS

Only in Long COVID

LPS Synthesis TransportAdhesion Invasion FactorsBile Salt Hydrolase (BSH)Polysaccharide DegradationLPS Biosynthesis EnzymesBeta Lactamases