Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

23%: weighted overlap
25: shared signals

First condition

Second condition

Comparison

Alzheimer's DiseaseandColorectal Cancer

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Alzheimer's Disease references
36: Colorectal Cancer references
0: shared references

Metals elevated or accumulated

6 shared

Metals depleted or redistributed

2 shared

Shared

Zinc Selenium

Only in Alzheimer's Disease

CopperCopper BrainZinc SerumGlutathione (GSH)

Only in Colorectal Cancer

Butyrate Manganese

Taxa enriched

4 shared

Shared

Escherichia coli Bacteroides fragilis Akkermansia muciniphila Candida albicans

Only in Alzheimer's Disease

Helicobacter pylori Klebsiella pneumoniae Prevotella

Only in Colorectal Cancer

Fusobacterium nucleatum Fusobacterium varium Parvimonas micra Peptostreptococcus stomatis Clostridium symbiosum Porphyromonas gingivalis Peptostreptococcus anaerobius Enterococcus faecalis Streptococcus gallolyticus Saccharomyces cerevisiae

Taxa depleted

4 shared

Shared

Lachnospiraceae Ruminococcus Roseburia Faecalibacterium prausnitzii

Only in Alzheimer's Disease

Saccharomyces Blautia Eubacterium rectale Bacteroides

Only in Colorectal Cancer

Prevotella copri Ruminococcus albus Dialister Bifidobacterium Lactobacillus

Host response elevated

3 shared

Shared

Hepcidin Lipocalin-2 Calprotectin (S100A8/A9)

Only in Alzheimer's Disease

Proinflammatory CytokinesTransferrin Receptor AlteredFerritin AlteredTREM2

Only in Colorectal Cancer

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)Lipopolysaccharide

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Alzheimer's Disease

ButyratePropionateIndole DerivativesTryptophan MetabolitesSelenoproteinsCeruloplasmin Function

Only in Colorectal Cancer

IL-10 (Interleukin-10)IgATreg CellsSelenium Dependent Glutathione Peroxidase

Ecological state

2 shared

Shared

HypoxiaSCFA Depletion

Only in Alzheimer's Disease

DysbiosisBarrier DysfunctionNeuroinflammationAmyloid SeedingMicroglial ActivationLPS TranslocationBlood Brain Barrier DisruptionAmyloid Cross SeedingLPS EndotoxemiaTMAO ElevationFerroptosisEpigenetic Latency

Only in Colorectal Cancer

BiofilmSecondary Bile Acid AccumulationFermentative Acidic MicroenvironmentEpithelial Barrier DisruptionColonic Serotonin DepletionAnaerobic DominanceSecondary Bile Acid ExcessWarburg EffectCross Kingdom DysbiosisVirome Network Disruption

Virulence and functional enzymes

3 shared

Shared

Siderophores Urease Beta-Glucuronidase

Only in Alzheimer's Disease

Curli FibersLipopolysaccharideBacterial AmyloidsMetalloproteasesNickel-UreaseCurli AmyloidLPS

Only in Colorectal Cancer

FadAFap2LPS TLR4BFT ToxinColibactin PksGlyoxalase IBFT Zinc MetalloproteaseColibactin GenotoxinFadA AdhesinFap2 LectinNAD(P)H Oxidase