Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

24%: weighted overlap
23: shared signals

First condition

Second condition

Comparison

Type 2 DiabetesandCardiovascular Disease

11 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

30: Type 2 Diabetes references
24: Cardiovascular Disease references
11: shared references

Metals elevated or accumulated

4 shared

Metals depleted or redistributed

2 shared

Shared

Glutathione (GSH)Manganese

Only in Type 2 Diabetes

Zinc Chromium Magnesium

Only in Cardiovascular Disease

Selenium Iron

Taxa enriched

4 shared

Shared

Escherichia coli Enterobacteriaceae Streptococcus Candida albicans

Only in Type 2 Diabetes

Prevotella Enterococcus Helicobacter pylori Campylobacter jejuni

Only in Cardiovascular Disease

Bacteroides fragilis Porphyromonas gingivalis Eggerthella lenta Ruminococcus gnavus Malassezia

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Lachnospiraceae Roseburia

Only in Type 2 Diabetes

Bifidobacterium Akkermansia muciniphila Ruminococcus Bacteroides fragilis Blautia

Only in Cardiovascular Disease

Allisonella Clostridium Clostridiales Mycobiome

Host response elevated

2 shared

Shared

Hepcidin Ceruloplasmin

Only in Type 2 Diabetes

LipopolysaccharideInflammatory CytokinesTNF-alpha (Tumor Necrosis Factor Alpha)IL 6Ferritin

Only in Cardiovascular Disease

Calprotectin (S100A8/A9)Transferrin Lipocalin-2Lipopolysaccharide LPS

Host response depleted

4 shared

Shared

ButyratePropionateAcetate Glutathione (GSH)

Only in Type 2 Diabetes

Bile AcidsZinc Chromium Manganese Magnesium

Only in Cardiovascular Disease

SeleniumSelenoproteinsGlutathione Peroxidase

Ecological state

1 shared

Shared

Endotoxemia

Only in Type 2 Diabetes

DysbiosisSCFA DepletionLPS ElevationBile Acid DysmetabolismImpaired Intestinal BarrierLipid PeroxidationReduced Microbial DiversityGut Barrier DisruptionBile Acid DysregulationIron Overload Oxidative StressFungal Overgrowth

Only in Cardiovascular Disease

HypoxiaTMAO Production DominanceLPS EndotoxemiaIndoxyl Sulfate AccumulationReduced Butyrate EcosystemFunctional ShieldingOral To Gut TranslocationBiofilmOral Gut TranslocationTMAO AccumulationFungal Bacterial Co Dysbiosis

Virulence and functional enzymes

3 shared

Shared

SiderophoresLPS Biosynthesis EnzymesTMA Lyase CutC CutD

Only in Type 2 Diabetes

LipopolysaccharideCholine TMA LyaseBile Acid DehydrataseCarbohydrate Fermentation EnzymesNickel-Urease

Only in Cardiovascular Disease

TMA Lyase CutC/DLipopolysaccharide LPS BiosynthesisSiderophores Enterobactin YersiniabactinBeta-GlucuronidaseTryptophanaseIndole ProductionHSP60