Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

9%: weighted overlap
7: shared signals

First condition

Second condition

Comparison

Rheumatoid ArthritisandGastroesophageal Reflux Disease (GERD)

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

7: Rheumatoid Arthritis references
16: Gastroesophageal Reflux Disease (GERD) references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

Copper Lead Cadmium Chromium Arsenic

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 MetalsNickel

Metals depleted or redistributed

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

Vitamin D Nickel

Only in Gastroesophageal Reflux Disease (GERD)

Glutathione (GSH)Iron Zinc Magnesium Calcium

Taxa enriched

3 shared

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Lachnospiraceae Bifidobacterium

Only in Rheumatoid Arthritis

Bacteroides fragilis

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Blautia Akkermansia muciniphila Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Host response elevated

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

Ceruloplasmin Hepcidin Calprotectin (S100A8/A9)

Only in Gastroesophageal Reflux Disease (GERD)

IL 6IL-8 (Interleukin-8 / CXCL8)NF KappaBTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Rheumatoid Arthritis

Vitamin D

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic Cells

Ecological state

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

Mucosal Origin AutoimmunityBarrier DysfunctionMolecular MimicryTh17 DominanceMetal VitD Bone AxisSoil Food Chain Exposure

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

MetalloproteinasesSiderophoresLPS Biosynthesis Enzymes

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseLPS BiosynthesisArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal LipasesBeta-Glucuronidase