Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

9%: weighted overlap
8: shared signals

First condition

Second condition

Comparison

Parkinson's DiseaseandFibromyalgia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

38: Parkinson's Disease references
9: Fibromyalgia references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Copper

Only in Parkinson's Disease

Iron Manganese Lead NickelIron Substantia NigraManganese Basal GangliaCadmium Mercury

Only in Fibromyalgia

None indexed

Metals depleted or redistributed

2 shared

Shared

Glutathione (GSH)Selenium

Only in Parkinson's Disease

ZincCopper BrainZinc Serum

Only in Fibromyalgia

Iron Magnesium

Taxa enriched

0 shared

Shared

None indexed

Only in Parkinson's Disease

Enterobacteriaceae Akkermansia muciniphila Candida albicans Escherichia coli Porphyromonas Lactobacillus Helicobacter pylori

Only in Fibromyalgia

Eggerthella Flavonifractor Coprococcus Streptococcus Collinsella Eggerthella lentaCoprococcus 2

Taxa depleted

3 shared

Host response elevated

0 shared

Shared

None indexed

Only in Parkinson's Disease

Hepcidin Calprotectin (S100A8/A9)Transferrin Lipocalin-2Inflammatory Cytokines TNF IL6 IL1betaFerritinTransferrin Receptor Altered

Only in Fibromyalgia

CeruloplasminPro Inflammatory CytokinesCopperSerum ButyrateTNF-alpha (Tumor Necrosis Factor Alpha)IL 6

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Parkinson's Disease

Lactoferrin Short-Chain Fatty Acids (SCFAs)GPX4SelenoproteinsNeuromelanin Iron Binding Capacity

Only in Fibromyalgia

GPX3Ferritin Iron SeleniumGlutathione Peroxidase 3Serotonin

Ecological state

1 shared

Shared

SCFA Depletion

Only in Parkinson's Disease

HypoxiaIron Rich MicroenvironmentFunctional ShieldingBacterial TranslocationGut PermeabilityDysbiotic FermentationAcidic Microenvironment FerroptosisAlpha Synuclein Gut SeedingBlood Brain Barrier DisruptionLPS EndotoxemiaVagal Nerve PropagationHypoxia GutSiderophore Competition

Only in Fibromyalgia

Butyrate ParadoxBarrier DysfunctionTryptophan Kynurenine ShuntingCopper Iron Axis ImbalanceCentral SensitizationGut Barrier Dysfunction

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Parkinson's Disease

Iron SiderophoresZinc-Metalloprotease Nickel-UreaseNickel HydrogenaseMucinaseLipopolysaccharide LPSBacterial Amyloids CurliNiFe-HydrogenaseCurli AmyloidLPSSiderophores

Only in Fibromyalgia

TryptophanasePro Inflammatory Metabolite SynthesisCopper Dependent OxidasesIndoleamine 2 3 DioxygenaseLPS BiosynthesisNeurotoxic Metabolite Production