Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

18%: weighted overlap
16: shared signals

First condition

Second condition

Comparison

ObesityandType 1 Diabetes

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Obesity references
20: Type 1 Diabetes references
0: shared references

Metals elevated or accumulated

3 shared

Metals depleted or redistributed

1 shared

Shared

Glutathione (GSH)

Only in Obesity

Magnesium Barium Vanadium Titanium

Only in Type 1 Diabetes

Zinc Selenium

Taxa enriched

3 shared

Shared

Escherichia coli Streptococcus Enterobacteriaceae

Only in Obesity

Fusobacterium Bacteroides fragilis

Only in Type 1 Diabetes

Bacteroides Ruminococcus gnavus Veillonella Sutterella Akkermansia muciniphila Prevotellaceae

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Roseburia Lachnospiraceae Bifidobacterium

Only in Obesity

Akkermansia muciniphila Oscillospiraceae

Only in Type 1 Diabetes

Subdoligranulum Eubacterium rectale Prevotella LactobacillusClostridium Clusters IV/XIVaBlautia Eubacterium eligens Clostridium

Host response elevated

2 shared

Shared

Hepcidin Ferritin

Only in Obesity

Calprotectin (S100A8/A9)Transferrin Lipocalin-2 Lactoferrin

Only in Type 1 Diabetes

ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationAnti ZnT8 Autoantibodies

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Obesity

Butyrate Short-Chain Fatty Acids (SCFAs)

Only in Type 1 Diabetes

Treg FunctionGPR43 SCFA SignalingZinc BioavailabilityZinc Metallothionein

Ecological state

0 shared

Shared

None indexed

Only in Obesity

HypoxiaMetal Driven DysbiosisReduced SCFA ProductionIncreased LPSEndotoxemiaIntestinal Permeability IncreaseFermentative Metabolism Acidic MicroenvironmentMetabolic EndotoxemiaReduced Microbial DiversityIncreased Energy HarvestBile Acid DysregulationVirome Depletion

Only in Type 1 Diabetes

Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window

Virulence and functional enzymes

2 shared

Shared

LPS BiosynthesisBeta-Glucuronidase

Only in Obesity

TMA LyaseSiderophores Nickel-UreaseNickel HydrogenaseZinc Metalloproteases

Only in Type 1 Diabetes

LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine Methyltransferases