Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

13%: weighted overlap
14: shared signals

First condition

Second condition

Comparison

Long COVIDandParkinson's Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

18: Long COVID references
38: Parkinson's Disease references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Long COVID

Zinc Arsenic Thallium

Only in Parkinson's Disease

Iron Manganese Lead Nickel CopperIron Substantia NigraManganese Basal GangliaCadmium Mercury

Metals depleted or redistributed

2 shared

Shared

Selenium Glutathione (GSH)

Only in Long COVID

Iron Copper Nickel

Only in Parkinson's Disease

ZincCopper BrainZinc Serum

Taxa enriched

3 shared

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Roseburia Lachnospiraceae

Only in Long COVID

Bifidobacterium Lactobacillus Akkermansia muciniphila

Only in Parkinson's Disease

PrevotellaLactic Acid BacteriaBlautia Coprococcus

Host response elevated

2 shared

Shared

Hepcidin Calprotectin (S100A8/A9)

Only in Long COVID

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)IFN-gamma (Interferon Gamma)LPS In CirculationPD 1 On CD8TIM 3 On CD8AutoantibodiesZinc In Secretions

Only in Parkinson's Disease

Transferrin Lipocalin-2Inflammatory Cytokines TNF IL6 IL1betaFerritinTransferrin Receptor Altered

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Long COVID

Regulatory T CellsNK Cell FunctionMemory B CellsSIgAButyrate SeleniumIron In Tissues

Only in Parkinson's Disease

Lactoferrin Short-Chain Fatty Acids (SCFAs)GPX4SelenoproteinsNeuromelanin Iron Binding Capacity

Ecological state

2 shared

Shared

Bacterial TranslocationSCFA Depletion

Only in Long COVID

Self Perpetuating Dysbiosis LoopAnaerobe To Aerobe ShiftSCFA CollapseBacterial Translocation EndotoxemiaGut Lung Axis DisruptionGut Brain Axis DisruptionTryptophan AhR DysmetabolismVirome Co DysbiosisMulti Kingdom DysbiosisNon Linear Recovery TrajectoryStrain Level Diversity CollapseEstrobolome DysfunctionUremic Metabolite AccumulationHypoxia CellularAerobe BloomBarrier DysfunctionMulti Kingdom Co DysbiosisNon Linear Recovery

Only in Parkinson's Disease

HypoxiaIron Rich MicroenvironmentFunctional ShieldingGut PermeabilityDysbiotic FermentationAcidic Microenvironment FerroptosisAlpha Synuclein Gut SeedingBlood Brain Barrier DisruptionLPS EndotoxemiaVagal Nerve PropagationHypoxia GutSiderophore Competition

Virulence and functional enzymes

1 shared

Shared

Siderophores

Only in Long COVID

LPS Synthesis TransportAdhesion Invasion FactorsBile Salt Hydrolase (BSH)Beta-GlucuronidasePolysaccharide DegradationLPS Biosynthesis EnzymesBeta Lactamases

Only in Parkinson's Disease

Iron SiderophoresZinc-Metalloprotease Nickel-UreaseNickel HydrogenaseMucinaseLipopolysaccharide LPSBacterial Amyloids CurliNiFe-HydrogenaseCurli AmyloidLPS