Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

9%: weighted overlap
7: shared signals

First condition

Second condition

Comparison

Gastroesophageal Reflux Disease (GERD)andRheumatoid Arthritis

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

16: Gastroesophageal Reflux Disease (GERD) references
7: Rheumatoid Arthritis references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 MetalsNickel

Only in Rheumatoid Arthritis

Copper Lead Cadmium Chromium Arsenic

Metals depleted or redistributed

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Glutathione (GSH)Iron Zinc Magnesium Calcium

Only in Rheumatoid Arthritis

Vitamin D Nickel

Taxa enriched

3 shared

Taxa depleted

3 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Lachnospiraceae

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Blautia Akkermansia muciniphila Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Only in Rheumatoid Arthritis

Bacteroides fragilis

Host response elevated

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

IL 6IL-8 (Interleukin-8 / CXCL8)NF KappaBTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Only in Rheumatoid Arthritis

Ceruloplasmin Hepcidin Calprotectin (S100A8/A9)

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic Cells

Only in Rheumatoid Arthritis

Vitamin D

Ecological state

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Only in Rheumatoid Arthritis

Mucosal Origin AutoimmunityBarrier DysfunctionMolecular MimicryTh17 DominanceMetal VitD Bone AxisSoil Food Chain Exposure

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseLPS BiosynthesisArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal LipasesBeta-Glucuronidase

Only in Rheumatoid Arthritis

MetalloproteinasesSiderophoresLPS Biosynthesis Enzymes