Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

12%: weighted overlap
12: shared signals

First condition

Second condition

Comparison

Gastroesophageal Reflux Disease (GERD)andFibromyalgia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

16: Gastroesophageal Reflux Disease (GERD) references
9: Fibromyalgia references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 MetalsNickel

Only in Fibromyalgia

Copper

Metals depleted or redistributed

3 shared

Taxa enriched

2 shared

Shared

Collinsella Eggerthella

Only in Gastroesophageal Reflux Disease (GERD)

Prevotella Pseudomonas Veillonella Leptotrichia Fusobacterium Enterobacteriaceae Escherichia coli Bacteroides Candida albicans Fusobacterium nucleatum Mollicutes

Only in Fibromyalgia

Flavonifractor Coprococcus Streptococcus Eggerthella lentaCoprococcus 2

Taxa depleted

3 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Lachnospiraceae

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Blautia Akkermansia muciniphila Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Only in Fibromyalgia

Bacteroides vulgatus Roseburia Bacteroides uniformis

Host response elevated

2 shared

Shared

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)

Only in Gastroesophageal Reflux Disease (GERD)

IL-8 (Interleukin-8 / CXCL8)NF KappaBIL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Only in Fibromyalgia

CeruloplasminPro Inflammatory CytokinesCopperSerum Butyrate

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic Cells

Only in Fibromyalgia

GPX3Ferritin Iron SeleniumGlutathione Peroxidase 3Serotonin

Ecological state

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Only in Fibromyalgia

SCFA DepletionButyrate ParadoxBarrier DysfunctionTryptophan Kynurenine ShuntingCopper Iron Axis ImbalanceCentral SensitizationGut Barrier Dysfunction

Virulence and functional enzymes

1 shared

Shared

LPS Biosynthesis

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal LipasesBeta-Glucuronidase

Only in Fibromyalgia

TryptophanasePro Inflammatory Metabolite SynthesisCopper Dependent OxidasesIndoleamine 2 3 DioxygenaseNeurotoxic Metabolite Production