Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

9%: weighted overlap
8: shared signals

First condition

Second condition

Comparison

FibromyalgiaandParkinson's Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

9: Fibromyalgia references
38: Parkinson's Disease references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Copper

Only in Fibromyalgia

None indexed

Only in Parkinson's Disease

Iron Manganese Lead NickelIron Substantia NigraManganese Basal GangliaCadmium Mercury

Metals depleted or redistributed

2 shared

Shared

Selenium Glutathione (GSH)

Only in Fibromyalgia

Iron Magnesium

Only in Parkinson's Disease

ZincCopper BrainZinc Serum

Taxa enriched

0 shared

Shared

None indexed

Only in Fibromyalgia

Eggerthella Flavonifractor Coprococcus Streptococcus Collinsella Eggerthella lentaCoprococcus 2

Only in Parkinson's Disease

Enterobacteriaceae Akkermansia muciniphila Candida albicans Escherichia coli Porphyromonas Lactobacillus Helicobacter pylori

Taxa depleted

3 shared

Host response elevated

0 shared

Shared

None indexed

Only in Fibromyalgia

CeruloplasminPro Inflammatory CytokinesCopperSerum ButyrateTNF-alpha (Tumor Necrosis Factor Alpha)IL 6

Only in Parkinson's Disease

Hepcidin Calprotectin (S100A8/A9)Transferrin Lipocalin-2Inflammatory Cytokines TNF IL6 IL1betaFerritinTransferrin Receptor Altered

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Fibromyalgia

GPX3Ferritin Iron SeleniumGlutathione Peroxidase 3Serotonin

Only in Parkinson's Disease

Lactoferrin Short-Chain Fatty Acids (SCFAs)GPX4SelenoproteinsNeuromelanin Iron Binding Capacity

Ecological state

1 shared

Shared

SCFA Depletion

Only in Fibromyalgia

Butyrate ParadoxBarrier DysfunctionTryptophan Kynurenine ShuntingCopper Iron Axis ImbalanceCentral SensitizationGut Barrier Dysfunction

Only in Parkinson's Disease

HypoxiaIron Rich MicroenvironmentFunctional ShieldingBacterial TranslocationGut PermeabilityDysbiotic FermentationAcidic Microenvironment FerroptosisAlpha Synuclein Gut SeedingBlood Brain Barrier DisruptionLPS EndotoxemiaVagal Nerve PropagationHypoxia GutSiderophore Competition

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Fibromyalgia

TryptophanasePro Inflammatory Metabolite SynthesisCopper Dependent OxidasesIndoleamine 2 3 DioxygenaseLPS BiosynthesisNeurotoxic Metabolite Production

Only in Parkinson's Disease

Iron SiderophoresZinc-Metalloprotease Nickel-UreaseNickel HydrogenaseMucinaseLipopolysaccharide LPSBacterial Amyloids CurliNiFe-HydrogenaseCurli AmyloidLPSSiderophores