Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

12%: weighted overlap
12: shared signals

First condition

Second condition

Comparison

FibromyalgiaandGastroesophageal Reflux Disease (GERD)

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

9: Fibromyalgia references
16: Gastroesophageal Reflux Disease (GERD) references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Fibromyalgia

Copper

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 MetalsNickel

Metals depleted or redistributed

3 shared

Taxa enriched

2 shared

Shared

Eggerthella Collinsella

Only in Fibromyalgia

Flavonifractor Coprococcus Streptococcus Eggerthella lentaCoprococcus 2

Only in Gastroesophageal Reflux Disease (GERD)

Prevotella Pseudomonas Veillonella Leptotrichia Fusobacterium Enterobacteriaceae Escherichia coli Bacteroides Candida albicans Fusobacterium nucleatum Mollicutes

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Lachnospiraceae

Only in Fibromyalgia

Bacteroides vulgatus Roseburia Bacteroides uniformis

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Blautia Akkermansia muciniphila Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Host response elevated

2 shared

Shared

TNF-alpha (Tumor Necrosis Factor Alpha)IL 6

Only in Fibromyalgia

CeruloplasminPro Inflammatory CytokinesCopperSerum Butyrate

Only in Gastroesophageal Reflux Disease (GERD)

IL-8 (Interleukin-8 / CXCL8)NF KappaBIL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Fibromyalgia

GPX3Ferritin Iron SeleniumGlutathione Peroxidase 3Serotonin

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic Cells

Ecological state

0 shared

Shared

None indexed

Only in Fibromyalgia

SCFA DepletionButyrate ParadoxBarrier DysfunctionTryptophan Kynurenine ShuntingCopper Iron Axis ImbalanceCentral SensitizationGut Barrier Dysfunction

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Virulence and functional enzymes

1 shared

Shared

LPS Biosynthesis

Only in Fibromyalgia

TryptophanasePro Inflammatory Metabolite SynthesisCopper Dependent OxidasesIndoleamine 2 3 DioxygenaseNeurotoxic Metabolite Production

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal LipasesBeta-Glucuronidase