Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
14: shared signals

First condition

Second condition

Comparison

DepressionandCerebral Palsy

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

38: Depression references
9: Cerebral Palsy references
0: shared references

Metals elevated or accumulated

2 shared

Metals depleted or redistributed

2 shared

Shared

Zinc Iron

Only in Depression

Magnesium Selenium

Only in Cerebral Palsy

None indexed

Taxa enriched

0 shared

Shared

None indexed

Only in Depression

Candida albicans Clostridium Bacteroides fragilis Escherichia coli Eggerthella Enterobacteriaceae Flavonifractor

Only in Cerebral Palsy

Streptococcus Enterococcus Akkermansia muciniphila Prevotella Veillonella Klebsiella Klebsiella pneumoniae Fusobacterium

Taxa depleted

2 shared

Shared

Faecalibacterium prausnitzii Lactobacillus

Only in Depression

Bifidobacterium Lachnospiraceae Prevotella Coprococcus Dialister

Only in Cerebral Palsy

Bacteroides Blautia Ruminococcus Roseburia Bacteroides fragilis

Host response elevated

3 shared

Shared

Hepcidin Calprotectin (S100A8/A9)Pro Inflammatory Cytokines

Only in Depression

Ceruloplasmin Ferritin

Only in Cerebral Palsy

TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)IL 6IL-8 (Interleukin-8 / CXCL8)IL-10 (Interleukin-10)

Host response depleted

2 shared

Shared

Zinc Iron

Only in Depression

Magnesium Selenium Glutathione (GSH)Glutathione Peroxidase

Only in Cerebral Palsy

Butyrate Vitamin D

Ecological state

1 shared

Shared

SCFA Depletion

Only in Depression

DysbiosisLeaky GutIntestinal Permeability EndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation

Only in Cerebral Palsy

NEC To CP PathwayTLR4 LPS Microglial ActivationOral Gut Inflammatory AxisWhite Matter InjuryProteobacteria BloomKynurenine Pathway DysregulationOral Gut TranslocationMucin DegradationConstipation Driven Oxygen ShiftBiofilm

Virulence and functional enzymes

2 shared

Shared

TryptophanaseLPS Biosynthesis

Only in Depression

Beta-GlucuronidasePro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli

Only in Cerebral Palsy

SiderophoresTLR4 LPS SignalingBeta Glucosidase