Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 23%
- weighted overlap
- 21
- shared signals
Comparison
DepressionandCardiovascular Disease
5 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 38
- Depression references
- 24
- Cardiovascular Disease references
- 5
- shared references
Metals depleted or redistributed
2 sharedTaxa enriched
4 sharedShared
Only in Depression
Only in Cardiovascular Disease
Taxa depleted
2 sharedShared
Only in Depression
Only in Cardiovascular Disease
Host response elevated
3 sharedHost response depleted
3 sharedEcological state
1 sharedShared
Only in Depression
DysbiosisLeaky GutIntestinal PermeabilityLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOSCFA DepletionHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation
Only in Cardiovascular Disease
HypoxiaTMAO Production DominanceLPS EndotoxemiaIndoxyl Sulfate AccumulationReduced Butyrate EcosystemFunctional ShieldingOral To Gut TranslocationBiofilmOral Gut TranslocationTMAO AccumulationFungal Bacterial Co Dysbiosis
Virulence and functional enzymes
3 sharedShared
Only in Depression
LPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseBacterial Amyloids Curli
Only in Cardiovascular Disease
TMA Lyase CutC/DLipopolysaccharide LPS BiosynthesisSiderophores Enterobactin YersiniabactinIndole ProductionHSP60TMA Lyase CutC CutDSiderophores