Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

11%: weighted overlap
12: shared signals

First condition

Second condition

Comparison

Cerebral PalsyandGastroesophageal Reflux Disease (GERD)

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

9: Cerebral Palsy references
16: Gastroesophageal Reflux Disease (GERD) references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Cerebral Palsy

Lead Arsenic Copper

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 MetalsNickel

Metals depleted or redistributed

2 shared

Shared

Iron Zinc

Only in Cerebral Palsy

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Glutathione (GSH)Magnesium Calcium

Taxa enriched

3 shared

Taxa depleted

2 shared

Shared

Faecalibacterium prausnitzii Blautia

Only in Cerebral Palsy

Bacteroides Ruminococcus Roseburia Lactobacillus Bacteroides fragilis

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Bifidobacterium Lachnospiraceae Akkermansia muciniphila Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Host response elevated

4 shared

Shared

TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)IL 6IL-8 (Interleukin-8 / CXCL8)

Only in Cerebral Palsy

Pro Inflammatory CytokinesCalprotectin (S100A8/A9)IL-10 (Interleukin-10)Hepcidin

Only in Gastroesophageal Reflux Disease (GERD)

NF KappaBTLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Host response depleted

0 shared

Shared

None indexed

Only in Cerebral Palsy

Iron Zinc Butyrate Vitamin D

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic CellsGlutathione (GSH)

Ecological state

0 shared

Shared

None indexed

Only in Cerebral Palsy

NEC To CP PathwayTLR4 LPS Microglial ActivationOral Gut Inflammatory AxisWhite Matter InjurySCFA DepletionProteobacteria BloomKynurenine Pathway DysregulationOral Gut TranslocationMucin DegradationConstipation Driven Oxygen ShiftBiofilm

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Virulence and functional enzymes

1 shared

Shared

LPS Biosynthesis

Only in Cerebral Palsy

SiderophoresTryptophanaseTLR4 LPS SignalingBeta Glucosidase

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal LipasesBeta-Glucuronidase