Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

24%: weighted overlap
23: shared signals

First condition

Second condition

Comparison

Cardiovascular DiseaseandType 2 Diabetes

11 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

24: Cardiovascular Disease references
30: Type 2 Diabetes references
11: shared references

Metals elevated or accumulated

4 shared

Metals depleted or redistributed

2 shared

Shared

Glutathione (GSH)Manganese

Only in Cardiovascular Disease

Selenium Iron

Only in Type 2 Diabetes

Zinc Chromium Magnesium

Taxa enriched

4 shared

Shared

Enterobacteriaceae Escherichia coli Streptococcus Candida albicans

Only in Cardiovascular Disease

Bacteroides fragilis Porphyromonas gingivalis Eggerthella lenta Ruminococcus gnavus Malassezia

Only in Type 2 Diabetes

Prevotella Enterococcus Helicobacter pylori Campylobacter jejuni

Taxa depleted

3 shared

Shared

Roseburia Faecalibacterium prausnitzii Lachnospiraceae

Only in Cardiovascular Disease

Allisonella Clostridium Clostridiales Mycobiome

Only in Type 2 Diabetes

Bifidobacterium Akkermansia muciniphila Ruminococcus Bacteroides fragilis Blautia

Host response elevated

2 shared

Shared

Hepcidin Ceruloplasmin

Only in Cardiovascular Disease

Calprotectin (S100A8/A9)Transferrin Lipocalin-2Lipopolysaccharide LPS

Only in Type 2 Diabetes

LipopolysaccharideInflammatory CytokinesTNF-alpha (Tumor Necrosis Factor Alpha)IL 6Ferritin

Host response depleted

4 shared

Shared

Glutathione (GSH)ButyratePropionateAcetate

Only in Cardiovascular Disease

SeleniumSelenoproteinsGlutathione Peroxidase

Only in Type 2 Diabetes

Bile AcidsZinc Chromium Manganese Magnesium

Ecological state

1 shared

Shared

Endotoxemia

Only in Cardiovascular Disease

HypoxiaTMAO Production DominanceLPS EndotoxemiaIndoxyl Sulfate AccumulationReduced Butyrate EcosystemFunctional ShieldingOral To Gut TranslocationBiofilmOral Gut TranslocationTMAO AccumulationFungal Bacterial Co Dysbiosis

Only in Type 2 Diabetes

DysbiosisSCFA DepletionLPS ElevationBile Acid DysmetabolismImpaired Intestinal BarrierLipid PeroxidationReduced Microbial DiversityGut Barrier DisruptionBile Acid DysregulationIron Overload Oxidative StressFungal Overgrowth

Virulence and functional enzymes

3 shared

Shared

TMA Lyase CutC CutDLPS Biosynthesis EnzymesSiderophores

Only in Cardiovascular Disease

TMA Lyase CutC/DLipopolysaccharide LPS BiosynthesisSiderophores Enterobactin YersiniabactinBeta-GlucuronidaseTryptophanaseIndole ProductionHSP60

Only in Type 2 Diabetes

LipopolysaccharideCholine TMA LyaseBile Acid DehydrataseCarbohydrate Fermentation EnzymesNickel-Urease