Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

23%: weighted overlap
21: shared signals

First condition

Second condition

Comparison

Cardiovascular DiseaseandDepression

5 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

24: Cardiovascular Disease references
38: Depression references
5: shared references

Metals elevated or accumulated

3 shared

Metals depleted or redistributed

2 shared

Shared

Selenium Iron

Only in Cardiovascular Disease

Glutathione (GSH)Manganese

Only in Depression

Zinc Magnesium

Taxa enriched

4 shared

Shared

Enterobacteriaceae Escherichia coli Bacteroides fragilis Candida albicans

Only in Cardiovascular Disease

Streptococcus Porphyromonas gingivalis Eggerthella lenta Ruminococcus gnavus Malassezia

Only in Depression

Clostridium Eggerthella Flavonifractor

Taxa depleted

2 shared

Shared

Faecalibacterium prausnitzii Lachnospiraceae

Only in Cardiovascular Disease

Roseburia Allisonella Clostridium Clostridiales Mycobiome

Only in Depression

Bifidobacterium Prevotella Coprococcus Dialister Lactobacillus

Host response elevated

3 shared

Shared

Calprotectin (S100A8/A9)Hepcidin Ceruloplasmin

Only in Cardiovascular Disease

Transferrin Lipocalin-2Lipopolysaccharide LPS

Only in Depression

Pro Inflammatory CytokinesFerritin

Host response depleted

3 shared

Shared

Glutathione (GSH)SeleniumGlutathione Peroxidase

Only in Cardiovascular Disease

ButyratePropionateAcetateSelenoproteins

Only in Depression

Zinc Magnesium Iron

Ecological state

1 shared

Shared

Endotoxemia

Only in Cardiovascular Disease

HypoxiaTMAO Production DominanceLPS EndotoxemiaIndoxyl Sulfate AccumulationReduced Butyrate EcosystemFunctional ShieldingOral To Gut TranslocationBiofilmOral Gut TranslocationTMAO AccumulationFungal Bacterial Co Dysbiosis

Only in Depression

DysbiosisLeaky GutIntestinal PermeabilityLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOSCFA DepletionHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation

Virulence and functional enzymes

3 shared

Shared

Beta-GlucuronidaseTryptophanaseLPS Biosynthesis Enzymes

Only in Cardiovascular Disease

TMA Lyase CutC/DLipopolysaccharide LPS BiosynthesisSiderophores Enterobactin YersiniabactinIndole ProductionHSP60TMA Lyase CutC CutDSiderophores

Only in Depression

LPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseBacterial Amyloids Curli