Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

13%: weighted overlap
15: shared signals

First condition

Second condition

Comparison

Cardiovascular DiseaseandAutism Spectrum Disorder

1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

24: Cardiovascular Disease references
32: Autism Spectrum Disorder references
1: shared references

Metals elevated or accumulated

4 shared

Metals depleted or redistributed

3 shared

Shared

Selenium Glutathione (GSH)Iron

Only in Cardiovascular Disease

Manganese

Only in Autism Spectrum Disorder

Zinc

Taxa enriched

0 shared

Shared

None indexed

Only in Cardiovascular Disease

Enterobacteriaceae Escherichia coli Streptococcus Bacteroides fragilis Porphyromonas gingivalis Eggerthella lenta Ruminococcus gnavus Candida albicans Malassezia

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium CoprostanoligenesDesulfovibrio

Taxa depleted

2 shared

Shared

Faecalibacterium prausnitzii Lachnospiraceae

Only in Cardiovascular Disease

Roseburia Allisonella Clostridium Clostridiales Mycobiome

Only in Autism Spectrum Disorder

Coprococcus Bifidobacterium Lactobacillus

Host response elevated

4 shared

Shared

Calprotectin (S100A8/A9)Transferrin Hepcidin Lipocalin-2

Only in Cardiovascular Disease

Lipopolysaccharide LPSCeruloplasmin

Only in Autism Spectrum Disorder

Lactoferrin TNF-alpha (Tumor Necrosis Factor Alpha)IL 1IL 6IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Cardiovascular Disease

ButyratePropionateAcetate SeleniumSelenoproteinsGlutathione Peroxidase

Only in Autism Spectrum Disorder

SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Ecological state

0 shared

Shared

None indexed

Only in Cardiovascular Disease

HypoxiaTMAO Production DominanceLPS EndotoxemiaIndoxyl Sulfate AccumulationReduced Butyrate EcosystemFunctional ShieldingOral To Gut TranslocationBiofilm EndotoxemiaOral Gut TranslocationTMAO AccumulationFungal Bacterial Co Dysbiosis

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Cardiovascular Disease

TMA Lyase CutC/DLipopolysaccharide LPS BiosynthesisSiderophores Enterobactin YersiniabactinTryptophanaseIndole ProductionHSP60TMA Lyase CutC CutDLPS Biosynthesis EnzymesSiderophores

Only in Autism Spectrum Disorder

ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production