Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 15%
- weighted overlap
- 17
- shared signals
Comparison
Autism Spectrum DisorderandAlzheimer's Disease
4 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 32
- Autism Spectrum Disorder references
- 31
- Alzheimer's Disease references
- 4
- shared references
Metals depleted or redistributed
3 sharedShared
Only in Autism Spectrum Disorder
Only in Alzheimer's Disease
Taxa enriched
0 sharedShared
None indexed
Only in Autism Spectrum Disorder
Only in Alzheimer's Disease
Taxa depleted
2 sharedShared
Only in Autism Spectrum Disorder
Only in Alzheimer's Disease
Host response elevated
3 sharedShared
Only in Autism Spectrum Disorder
LactoferrinTransferrinTNF-alpha (Tumor Necrosis Factor Alpha)IL 1IL 6IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines
Only in Alzheimer's Disease
Proinflammatory CytokinesTransferrin Receptor AlteredFerritin AlteredTREM2
Host response depleted
1 sharedShared
Only in Autism Spectrum Disorder
SulfateZincIL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD
Only in Alzheimer's Disease
Ecological state
1 sharedShared
Only in Autism Spectrum Disorder
Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceDevelopmental Vulnerability
Only in Alzheimer's Disease
HypoxiaDysbiosisBarrier DysfunctionAmyloid SeedingMicroglial ActivationLPS TranslocationBlood Brain Barrier DisruptionAmyloid Cross SeedingLPS EndotoxemiaSCFA DepletionTMAO ElevationFerroptosisEpigenetic Latency
Virulence and functional enzymes
1 sharedShared
Only in Autism Spectrum Disorder
ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production
Only in Alzheimer's Disease
Curli FibersLipopolysaccharideBacterial AmyloidsSiderophoresUreaseMetalloproteasesNickel-UreaseCurli AmyloidLPS