Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

26%: weighted overlap
25: shared signals

First condition

Second condition

Comparison

Alzheimer's DiseaseandType 2 Diabetes

2 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Alzheimer's Disease references
30: Type 2 Diabetes references
2: shared references

Metals elevated or accumulated

5 shared

Shared

Lead Cadmium Arsenic Iron Nickel

Only in Alzheimer's Disease

Manganese Copper Mercury AluminumZinc In Plaques

Only in Type 2 Diabetes

None indexed

Metals depleted or redistributed

2 shared

Shared

Zinc Glutathione (GSH)

Only in Alzheimer's Disease

Copper SeleniumCopper BrainZinc Serum

Only in Type 2 Diabetes

Chromium Magnesium Manganese

Taxa enriched

4 shared

Taxa depleted

5 shared

Shared

Lachnospiraceae Ruminococcus Roseburia Blautia Faecalibacterium prausnitzii

Only in Alzheimer's Disease

Saccharomyces Eubacterium rectale Bacteroides

Only in Type 2 Diabetes

Bifidobacterium Akkermansia muciniphila Bacteroides fragilis

Host response elevated

1 shared

Shared

Hepcidin

Only in Alzheimer's Disease

Lipocalin-2 Calprotectin (S100A8/A9)Proinflammatory CytokinesTransferrin Receptor AlteredFerritin AlteredTREM2

Only in Type 2 Diabetes

LipopolysaccharideInflammatory CytokinesTNF-alpha (Tumor Necrosis Factor Alpha)IL 6Ferritin Ceruloplasmin

Host response depleted

3 shared

Shared

Glutathione (GSH)ButyratePropionate

Only in Alzheimer's Disease

Indole DerivativesTryptophan MetabolitesSelenoproteinsCeruloplasmin Function

Only in Type 2 Diabetes

AcetateBile AcidsZinc Chromium Manganese Magnesium

Ecological state

2 shared

Shared

DysbiosisSCFA Depletion

Only in Alzheimer's Disease

HypoxiaBarrier DysfunctionNeuroinflammationAmyloid SeedingMicroglial ActivationLPS TranslocationBlood Brain Barrier DisruptionAmyloid Cross SeedingLPS EndotoxemiaTMAO ElevationFerroptosisEpigenetic Latency

Only in Type 2 Diabetes

LPS ElevationBile Acid DysmetabolismImpaired Intestinal BarrierLipid PeroxidationReduced Microbial DiversityEndotoxemiaGut Barrier DisruptionBile Acid DysregulationIron Overload Oxidative StressFungal Overgrowth

Virulence and functional enzymes

3 shared

Shared

Lipopolysaccharide Siderophores Nickel-Urease

Only in Alzheimer's Disease

Curli FibersBacterial AmyloidsUreaseMetalloproteasesCurli AmyloidLPSBeta-Glucuronidase

Only in Type 2 Diabetes

Choline TMA LyaseBile Acid DehydrataseCarbohydrate Fermentation EnzymesLPS Biosynthesis EnzymesTMA Lyase CutC CutD