WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions, filtered to signature.
The most common form of dementia, affecting an estimated 55 million people worldwide and projected to triple by 2050 zhang 2024 recent advances alzheimers mechanisms trials. Characterized by progressive memory loss, cognitive decline, amyloid-beta plaques, and neurofibr…
Atherosclerosis is a chronic inflammatory disease of arterial walls characterized by lipid-laden plaque formation, endothelial dysfunction, and progressive vascular occlusion. It is the pathological substrate underlying coronary artery disease, stroke, and peripheral ar…
A neurodevelopmental condition affecting approximately 1 in 36 children (US CDC 2023 estimate), characterized by differences in social communication, restricted interests, and repetitive behaviors. From a metallomics perspective, ASD presents a compelling convergence of…
Breast cancer is the most common cancer in women worldwide, with approximately 2.3 million new cases annually. While genetic, hormonal, and lifestyle factors are well-established risk determinants, the metallomic dimension reveals a consistent pattern of trace element d…
Cardiovascular disease (CVD) -- encompassing atherosclerosis, coronary artery disease, hypertension, myocardial infarction, heart failure, and stroke -- is the leading cause of death globally. The gut-heart axis has emerged as a central paradigm linking microbial metabo…
Celiac disease is a chronic autoimmune condition triggered by dietary gluten (gliadin proteins from wheat, barley, and rye) in genetically susceptible individuals (HLA-DQ2/DQ8, carried by ~30-40% of Europeans but penetrant in only ~1% of carriers). Gluten exposure cause…
A progressive loss of kidney function affecting approximately 850 million people worldwide (10–14% of adults), causing 1.2 million deaths annually. CKD is unique among diseases in this wiki because it occupies both sides of the metal-disease equation: heavy metals (Cd, …
A chronic, relapsing-remitting inflammatory bowel disease (IBD) characterized by transmural inflammation of the gastrointestinal tract, most commonly affecting the terminal ileum and colon but capable of involving any segment from mouth to anus zhang 2017 intestinal mic…
Endometriosis is a chronic estrogen-dependent inflammatory condition affecting approximately 10% of reproductive-age women, characterized by the growth of endometrial-like tissue outside the uterus colonetti 2023 gut vaginal microbiota endometriosis meta analysis. The c…
Affects approximately 48 million women worldwide (WHO global infertility prevalence estimates). From a microbiome-metallomics perspective, female infertility sits at the intersection of the estrobolome (microbial estrogen metabolism), heavy metal reproductive toxicity (…
The fifth most common cancer worldwide and third leading cause of cancer death, with over 1 million new cases annually. Gastric cancer stands unique in this wiki as the disease where a single microorganism -- helicobacter pylori -- provides the dominant causal pathway, …
Gastroesophageal reflux disease (GERD) is a chronic condition in which stomach acid or bile flows back into the esophagus, causing mucosal damage and symptoms such as heartburn and regurgitation. Affecting approximately 20% of Western populations, GERD is conventionally…
Hashimoto's thyroiditis (HT) is the most common autoimmune disease globally and the leading cause of hypothyroidism. Chronic lymphocytic infiltration of the thyroid gland progressively destroys follicular architecture, reducing thyroid hormone output. Prevalence is 5-10…
Sustained elevation of systemic blood pressure, affecting an estimated 1.3 billion adults worldwide and the leading modifiable risk factor for cardiovascular disease, stroke, and chronic kidney disease. The gut microbiome-blood pressure axis has emerged as a major resea…
A functional gastrointestinal disorder affecting 10-15% of the global population, characterized by chronic abdominal pain, bloating, and altered bowel habits (diarrhea-predominant, constipation-predominant, or mixed) without identifiable structural pathology. From a met…
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system, with a global prevalence of approximately 2.8 million attfield 2022 immunology ms nature review. The conventional framing centers on genetic susceptibility (HLA-DRB115:0…
A chronic metabolic condition affecting over 1 billion people globally, characterized by excess adipose tissue accumulation, systemic low-grade inflammation, and gut microbiome disruption pendergrass 2026 heavy metals obesity epidemic. From a metallomics perspective, ob…
Ovarian cancer is the most lethal gynecological malignancy, with approximately 314,000 new cases and 207,000 deaths annually worldwide. Its poor prognosis stems largely from late-stage diagnosis (70% at stage III/IV) and the development of chemoresistance. From a metall…
The second most common neurodegenerative disease, affecting over 10 million people worldwide dorsey 2018 parkinsons incidence meta analysis. Characterized by progressive loss of dopaminergic neurons in the substantia nigra, alpha-synuclein aggregation (Lewy bodies), and…
A metabolic-endocrine disorder affecting 6-20% of reproductive-age women worldwide, characterized by hyperandrogenism, oligo/anovulation, and polycystic ovary morphology (Rotterdam criteria) barrea 2019 mediterranean diet pcos. PCOS is the leading cause of anovulatory i…
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by symmetric polyarthritis with progressive joint destruction, affecting approximately 1% of the global population. The conventional framing centers on genetic susceptibility (HLA-DRB1 shar…
Type 1 diabetes is an autoimmune disease in which immune-mediated destruction of insulin-producing beta cells in the pancreatic islets of Langerhans leads to lifelong insulin dependence. T1D is fundamentally distinct from type 2 diabetes, which is characterized by insul…
Type 2 diabetes (T2D) is a metabolic disease characterized by insulin resistance and progressive beta-cell dysfunction, affecting over 500 million people worldwide (IDF Diabetes Atlas 2021). The conventional framing centers on caloric excess and sedentary behavior. The …