WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions, filtered to disease.
The most common form of dementia, affecting an estimated 55 million people worldwide and projected to triple by 2050 zhang 2024 recent advances alzheimers mechanisms trials. Characterized by progressive memory loss, cognitive decline, amyloid-beta plaques, and neurofibr…
Cerebral palsy (CP) is the most common motor disability in childhood, affecting 2-3 per 1,000 live births allen 2021 multi organ dysfunction cerebral palsy. Characterized by non-progressive disturbances in movement and posture arising from injury to the developing brain…
Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer death. Over 90% of cases are sporadic, driven by a complex interplay between genetic predisposition, dietary habits, gut microbiome composition, and environmental ex…
A chronic, relapsing-remitting inflammatory bowel disease (IBD) characterized by transmural inflammation of the gastrointestinal tract, most commonly affecting the terminal ileum and colon but capable of involving any segment from mouth to anus zhang 2017 intestinal mic…
Depression is the most prevalent mental health disorder globally, affecting over 280 million people zhu 2025 microbiota gut brain axis depression review, and one of the most metal-sensitive conditions in this wiki. It sits at the convergence of nearly every pathway cata…
Endometriosis is a chronic estrogen-dependent inflammatory condition affecting approximately 10% of reproductive-age women, characterized by the growth of endometrial-like tissue outside the uterus colonetti 2023 gut vaginal microbiota endometriosis meta analysis. The c…
Fibromyalgia (FM) is a chronic pain syndrome affecting 2-4% of the global population Heidari et al. 2017, characterized by widespread musculoskeletal pain, fatigue, cognitive dysfunction ("fibro fog"), and sleep disturbances. Conventionally attributed to central sensiti…
Hashimoto's thyroiditis (HT) is the most common autoimmune disease globally and the leading cause of hypothyroidism. Chronic lymphocytic infiltration of the thyroid gland progressively destroys follicular architecture, reducing thyroid hormone output. Prevalence is 5-10…
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system, with a global prevalence of approximately 2.8 million attfield 2022 immunology ms nature review. The conventional framing centers on genetic susceptibility (HLA-DRB115:0…
Necrotizing enterocolitis (NEC) is the most common and lethal gastrointestinal emergency in premature infants, affecting 5-12% of very low birth weight neonates (<1500 g) with mortality rates of 20-30%. Characterized by intestinal inflammation, necrosis, and perforation…
A chronic metabolic condition affecting over 1 billion people globally, characterized by excess adipose tissue accumulation, systemic low-grade inflammation, and gut microbiome disruption pendergrass 2026 heavy metals obesity epidemic. From a metallomics perspective, ob…
Ovarian cancer is the most lethal gynecological malignancy, with approximately 314,000 new cases and 207,000 deaths annually worldwide. Its poor prognosis stems largely from late-stage diagnosis (70% at stage III/IV) and the development of chemoresistance. From a metall…
Pancreatic cancer is the fifth leading cause of cancer death in Western nations, with rising incidence globally. Pancreatic ductal adenocarcinoma (PDAC) accounts for over 90% of cases. Five-year survival remains approximately 12%, owing to late-stage diagnosis, aggressi…
Pancreatitis is inflammation of the pancreas, occurring in acute (AP) and chronic (CP) forms. Acute pancreatitis ranges from mild self-limiting disease to severe necrotizing pancreatitis with 20-30% mortality. Chronic pancreatitis is a risk factor for pancreatic cancer …
The second most common neurodegenerative disease, affecting over 10 million people worldwide dorsey 2018 parkinsons incidence meta analysis. Characterized by progressive loss of dopaminergic neurons in the substantia nigra, alpha-synuclein aggregation (Lewy bodies), and…
A metabolic-endocrine disorder affecting 6-20% of reproductive-age women worldwide, characterized by hyperandrogenism, oligo/anovulation, and polycystic ovary morphology (Rotterdam criteria) barrea 2019 mediterranean diet pcos. PCOS is the leading cause of anovulatory i…
Postpartum depression (PPD) affects 10-20% of women after delivery, with profound consequences for maternal health, infant bonding, and child neurodevelopment chao 2025 microbiota gut brain perinatal depression. The standard framing centers on hormonal withdrawal (estro…
Type 2 diabetes (T2D) is a metabolic disease characterized by insulin resistance and progressive beta-cell dysfunction, affecting over 500 million people worldwide (IDF Diabetes Atlas 2021). The conventional framing centers on caloric excess and sedentary behavior. The …