Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

14%: weighted overlap
12: shared signals

First condition

Second condition

Comparison

Ulcerative ColitisandColorectal Cancer

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

6: Ulcerative Colitis references
36: Colorectal Cancer references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Copper

Only in Ulcerative Colitis

Iron LuminalThallium

Only in Colorectal Cancer

Iron Zinc Cadmium Lead Nickel Arsenic Chromium

Metals depleted or redistributed

3 shared

Shared

Zinc Selenium Manganese

Only in Ulcerative Colitis

Iron Systemic

Only in Colorectal Cancer

Butyrate

Taxa enriched

2 shared

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Roseburia Lachnospiraceae

Only in Ulcerative Colitis

Bacteroides

Only in Colorectal Cancer

Prevotella copri Ruminococcus albus Dialister Bifidobacterium Lactobacillus Ruminococcus

Host response elevated

2 shared

Shared

Calprotectin (S100A8/A9)Hepcidin

Only in Ulcerative Colitis

Lactoferrin Ceruloplasmin Copper

Only in Colorectal Cancer

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)Lipopolysaccharide Lipocalin-2

Host response depleted

0 shared

Shared

None indexed

Only in Ulcerative Colitis

Zinc SeleniumGlutathione Peroxidase

Only in Colorectal Cancer

IL-10 (Interleukin-10)IgATreg CellsSelenium Dependent Glutathione PeroxidaseGlutathione (GSH)

Ecological state

0 shared

Shared

None indexed

Only in Ulcerative Colitis

Iron Pathobiont Feedback LoopButyrate DepletionMucosal UlcerationBarrier DysfunctionTh17 Treg ImbalanceMucin Degradation

Only in Colorectal Cancer

Hypoxia BiofilmSecondary Bile Acid AccumulationFermentative Acidic MicroenvironmentEpithelial Barrier DisruptionColonic Serotonin DepletionAnaerobic DominanceSecondary Bile Acid ExcessSCFA DepletionWarburg EffectCross Kingdom DysbiosisVirome Network Disruption

Virulence and functional enzymes

1 shared

Shared

Siderophores

Only in Ulcerative Colitis

Iron Acquisition SystemsAdhesinsMucin Degrading Glycosidases

Only in Colorectal Cancer

FadAFap2LPS TLR4BFT ToxinColibactin PksUrease Glyoxalase I Beta-GlucuronidaseBFT Zinc MetalloproteaseColibactin GenotoxinFadA AdhesinFap2 LectinNAD(P)H Oxidase