Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

10%: weighted overlap
10: shared signals

First condition

Second condition

Comparison

Type 2 DiabetesandNecrotizing Enterocolitis

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

30: Type 2 Diabetes references
19: Necrotizing Enterocolitis references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Iron

Only in Type 2 Diabetes

Nickel Cadmium Arsenic Lead

Only in Necrotizing Enterocolitis

None indexed

Metals depleted or redistributed

1 shared

Shared

Zinc

Only in Type 2 Diabetes

Chromium Magnesium Glutathione (GSH)Manganese

Only in Necrotizing Enterocolitis

None indexed

Taxa enriched

2 shared

Shared

Escherichia coli Enterococcus

Only in Type 2 Diabetes

Enterobacteriaceae Streptococcus Prevotella Candida albicans Helicobacter pylori Campylobacter jejuni

Only in Necrotizing Enterocolitis

Klebsiella Clostridium perfringens Staphylococcus Klebsiella pneumoniaeClostridium Perfringens (Toxigenic)Sphingomonas Spp.Clostridium Spp. (Obligate Anaerobe Cluster)Bacteroides/Prevotella (Obligate Anaerobe Cluster)Staphylococcus epidermidis

Taxa depleted

1 shared

Host response elevated

2 shared

Shared

TNF-alpha (Tumor Necrosis Factor Alpha)IL 6

Only in Type 2 Diabetes

Lipopolysaccharide HepcidinInflammatory CytokinesFerritin Ceruloplasmin

Only in Necrotizing Enterocolitis

Calprotectin (S100A8/A9)Lactoferrin EndogenousPro Inflammatory CytokinesTLR4 ExpressionLPSIL-1beta (Interleukin-1 Beta)

Host response depleted

2 shared

Shared

Acetate Zinc

Only in Type 2 Diabetes

ButyratePropionateBile AcidsGlutathione (GSH)Chromium Manganese Magnesium

Only in Necrotizing Enterocolitis

DefensinsLactateSecretory IgA

Ecological state

0 shared

Shared

None indexed

Only in Type 2 Diabetes

DysbiosisSCFA DepletionLPS ElevationBile Acid DysmetabolismImpaired Intestinal BarrierLipid PeroxidationReduced Microbial DiversityEndotoxemiaGut Barrier DisruptionBile Acid DysregulationIron Overload Oxidative StressFungal Overgrowth

Only in Necrotizing Enterocolitis

Proteobacteria Bloom 2 Weeks Pre DiagnosisVirome Convergence 10 Days Pre OnsetTLR4 Upregulation In Premature EpitheliumBifidobacterium Absence As PreconditionHMO Mediated Colonization ResistanceFeed Forward Barrier DestructionProteobacteria BloomTLR4 Feed Forward LoopVirome ConvergenceImmature BarrierParenteral Iron OverloadBiofilmBile Acid Accumulation ASBT UpregulationMuc2 Depletion Mucosal Barrier FailureObligate Anaerobe Mucosal InvasionGut Brain Axis NDI RiskAntibiotic Driven Richness Nadir Week4

Virulence and functional enzymes

1 shared

Shared

Siderophores

Only in Type 2 Diabetes

LipopolysaccharideCholine TMA LyaseBile Acid DehydrataseCarbohydrate Fermentation EnzymesLPS Biosynthesis EnzymesNickel-UreaseTMA Lyase CutC CutD

Only in Necrotizing Enterocolitis

LPS BiosynthesisAlpha ToxinPerfringolysin OBiofilm Formation Enzymes